Elsevier, 2006. — 437 p. — ISBN13: 978-0-12-088561-9; ISBN10: 0-12-088561-1. Strategies for Drug Discovery A Survey of Novel Molecular Targets for Anticancer Drug Discovery John K. Buolamwini Overview of Growth Factor Induced Mitogenic Signaling Protein Kinases and Phosphatases Adapter Proteins GTP-Binding Proteins Oncogenic Transcription Factors Apoptosis, Cell Survival, and...
Taylor & Francis, 2005. - 451 p. Part 1 Perspectives on Virtual Screening Virtual Screening: Scope and Limitations Addressing the Virtual Screening Challenge: The Flex* Approach An Analysis of Critical Factors Affecting Docking and Scoring Part II Compound and Hit Suitability for Virtual Screening Compound Selection for Virtual Screening Experimental Identification of...
Kluwer Academic Publishers, 2002. — 555 p. Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.
Bentham Books, 2023. — 228 p. — ISBN: 978-981-5123-60-9. Frontiers in Clinical Drug Research – Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the series covers a range of topics including the medicinal...
Springer International, 2019. — 226 p. — ISBN: 978-3-030-04674-3. This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance...
Springer, 2019. — 220 p. — (Environmental Chemistry for a Sustainable World). — ISBN10: 3030018806, 13 978-3030018801. This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters...
Springer, 2019. — 290 p. — (Environmental Chemistry for a Sustainable World). — ISBN10: 3030018806, 13 978-3030018801. This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology. It comprises of seven chapters...
Bentham Science, 2011. — 283 p. Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control...
Bentham Science Publishers, 2014. — 295 p. Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. Onset of obesity in both the developing and the developed world has reached epidemic proportions. In response to this, efforts...
Bentham eBooks, 2014. — 370 p. — ISBN: 160805912X. This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput...
Bentham eBooks, 2017. — 211 p. — ISBN: 1681082926. This Book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the eBook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput...
Wiley, 2004. - 279 p. - The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies,...
Weinheim: Wiley-VCH, 2022. — 448 p. — (Methods and Principles in Medicinal Chemistry Series: Volume 82). — ISBN: 978-3-527-34781-0. Novel approaches in targeted drug delivery for both small molecule and biopharmaceutical drugs. Targeted Drug Delivery explores a new frontier in drug research that has become a focus for developing novel medications. The work discusses a wide...
Wiley-VCH, 2019. — 463 p. — (Methods and Principles in Medicinal Chemistry, Volume 76) — ISBN: 978-3-527-34396-6 Teaches future and current drug developers the latest innovations in drug formulation design and optimization.This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies,...
Springer, 2013 — 625 p. This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods,...
Second Edition. CRC Press, 2005. — 376 p. Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to...
Springer International Publishing AG, 2018. — 88 p. — ISBN: 3319732374. Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of...
Springer International Publishing AG, 2018. — 72 p. — ISBN: 3319732374. Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of...
Apple Academic Press, 2016. — 379 p. This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a...
The Royal Society of Chemistry, 2016. — 536 p. — (RSC Drug Discovery Series No. 53) — ISBN: 1782627863. Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and...
2nd edition. — Academic Press, 2021. — 725 p. — ISBN: 978-0-12-817214-8. Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host...
Wiley, 2003. - 262 p. - The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition...
Elsevier, 2019. — 317 p. — (Natural Product Drug Discovery). — ISBN: 978-0-12-816992-6. This book, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the...
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2002. 605 p. This book deals with established analgesics as well as with new chemical entities for established and new targets. Compounds are classified with respect to their physiological target. In every case the structural formula is given as well as further information e.g. on the pharmacological profile, synthetic routes or major...
Second Edition. — New York: Humana Press. 2014. — 596 p. Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug...
The Royal Society of Chemistry, 2018. — 337 p. Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including...
John Wiley & Sons, 2003. - 288 p. Introduction to Model Systems in Drug Discovery Growing Yeast for Fun and Profit: Use of Saccharomyces cerevisiae as a Model System in Drug Discovery Caenorhabditis elegans Functional Genomics in Drug Discovery: Expanding Paradigms Drosophila as a Tool for Drug Discovery Drosophila – a Model System for Targets and Lead Identification in Cancer...
Springer Nature, Singapore, Pte Ltd., 2017. — 667 p. — ISBN: 9789811061400. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications...
Springer Nature, Singapore, Pte Ltd., 2017. — 667 p. — ISBN: 9789811061400. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications...
Elsevier, 2020. — 385 p. — (Micro and Nano Technologies). — ISBN: 978-0-12-814527-2. This book explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in...
De Gruyter, 2021. — 441 p. Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead hit methods, docking algorithms, computational chiral compounds, structure-based drug design, GROMACS and NAMD, structural...
Walter de Gruyter GmbH, 2024. — 439 p. — ISBN: 978-3-11-120669-1. — Part of the multi-volume work Computational Drug Discovery and Delivery. Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead-hit methods,...
De Gruyter, 2024. — 449 p. The book bridges the gap between pharmaceutics and molecular modeling at the micro, meso, and macro scale. It covers Lipinski's rule of five, nanoparticulate drug delivery, computational prediction of drug solubility and ability to cross the blood-brain barrier, computer-based simulation of pharmacokinetic parameters, virtual screening of mucoadhesive...
Springer, 2019. — 147 p. — ISBN10: 9811336563. This book summarizes the recent advances in applications of starch in state-of-the-art drug carriers (hydrogel, micro- and nano-particulate carriers) with stimulus-responsive and target-specific properties. It also highlights the role of starch and its derivatives in transmucosal administration to improve the bioavailability of...
ITexLi, 2016. — 188 p. — ISBN: 9535128000 9535127993. — Medicine - drug discovery, pharmaceutical Sector. This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. This book will facilitate your efforts in drug discovery. Drug discovery involves multiple disciplines, technologies, and approaches....
Springer, 2016. — 100 p. This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The...
John Wiley & Sons, Inc., 2012. — 533 p. This book includes 14 chapters. Chapter 1 presents a historical view on dendrimer chemistry and gives supramolecular perspectives on dendrimers. Chapter 2 focuses on the physicochemical properties of dendrimers and dendrimer complexes. Chapter 3 discusses the use of dendrimers to tailor the physicochemical and therapeutic properties of...
Wiley, 2006. — 466 p. Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully...
Independently published, Zerotextspy, 2003. — 65 p. Manual for Drug Manufacture. This is an education process. The methods explained within this text file are proven syntheses for manufacturing drugs. You will also find a few sections in here that are focused towards extractions, and Growing.
Cambridge: RSC Pub, 2012. This book documents the latest research into the theory and application of force-fields, semi-empirical molecular orbital, density functional and ab initio calculations, Quantum Mechanical (QM) based modeling, Atoms in Molecules (AIM) approach, and biomolecular dynamics. It also covers theory and application of 2D cheminformatics, QSAR/QSPR, ADME...
John Wiley & Sons, Ltd, 2013. — 207 p. — ISBN: 978-1-118-35412-4. There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one...
The Royal Society of Chemistry, 2015. — 384 p. — (RSC Drug Discovery Series 39). — ISBN: 978-1-84973-186-7. Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both...
2nd edition. — CRC Press, 2012. — 762 p. History of each covered drug — a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery. Important biosynthetic approaches to "unnatural" natural products. Anticancer...
Wiley-VCH, 2023. — 379 p. — ISBN: 978‐3‐527‐35013‐1. Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical...
Wiley-VCH, 2024. — 344 p. Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases. With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data”...
Springer-Verlag Berlin Heidelberg 1999. (Softcover reprint of the hardcover I st edition 1999). ISBN: 978-3-540-65927-3. A cover story of Business Week Magazine in January 1984 stated "Biotech Comes of Age". In February 1986, Venture Magazine had a cover article entitled "The Biotech Revolution is Here". This article went on to say "New Genetic Technologies Will Transform Our...
Wiley, 2013. — 330 p. Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been...
John Wiley & Sons, Ltd, 2015. — 293 p. — (Advances in Pharmaceutical Technology). — ISBN: 978-1-118-73451-3 (cloth). This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the...
CRC Press, 2010. — 554 p. As a result of new statistical and mathematical approaches, improved visualization tools, and recognition by international regulatory groups, quantitative structure-activity relationships (QSARs) now play important roles in pharmacology for the design of new drugs as well as in toxicology and ecotoxicology for hazard identification and risk assessment....
Wiley, 2013. - 628 p. Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs...
Wiley, 2015. — 337 p. This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. Identifies promising new areas in peptide drug discovery Includes chapters on discovery from natural sources, metabolic modification, and drug delivery...
Academic Press, 2016. - 474 p. - Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications...
CRC Press, 2025. — 233 p. — ISBN: 9781032506234. — Drugs and the Pharmaceutical Sciences Series. This book focuses on the latest advances in computational de novo drug discovery methods, also known as generative drug discovery. This book describes the state‑of‑the‑art methods and applications for the de novo design of drug candidates using generative chemistry models, as well...
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2016. — 527 p. — (Methods and Principles in Medicinal Chemistry. Volume 67) — ISBN: 352733775X From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the...
Wiley, 2018. — 565 p. Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and...
Wiley‐VCH Verlag GmbH & Co., 2018. 467 p. The third volume of Successful Drug Discovery has a structural similarity to the first volume consisting of three parts: General Aspects, Drug Class Studies, and Case Histories. The book series supported by the International Union of Pure and Applied Chemistry (IUPAC) focuses on new drug discoveries.This volume investigates drug...
Wiley‐VCH Verlag GmbH & Co., 2019. 259 p. Provides unique insider insight into the current drug development process, and what it takes to achieve success. In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the...
Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA. – 2006. – 607 p. This book focuses on both structural and pharmacological analogues – that is, those analogues which have similar chemical and biological properties – although some examples are also included where the analogue is derived purely on a similar chemical or a similar biological basis (but not both). Within the book, it is...
Wiley-VCH Verlag & Co. KGaA, Weinheim, Germany, 2015. — 258 p. — ISBN: 3527336850 The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very...
New York, USA: John Wiley and Sons, Inc., 2002. — 1014 p. — ISBN: 0471407275. Drug Safety Evaluation presents an all-inclusive, practical guide for those who are responsible for ensuring the safety of drugs and biologics for patients, for health care providers, for those involved in the manufacture of medicinal products, and for all those who need to understand how the safety...
3rd edition. — Wiley, 2017. — 895 p. — ISBN: 978-1-119-09739-6 Drug Safety Evaluation, 3rd Edition helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development. It also explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity...
4th edition. — Wiley, 2023. — 964 p. — ISBN: 9781119755852. This fourth edition of Drug Safety Evaluation maintains the central objective of presenting an all-inclusive practical guide for those who are responsible for ensuring the safety of drugs and biologics to patients, healthcare providers, those involved in the manufacture of medicinal products, and all those who need to...
Elsevier, 2013. - 445 p. - Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs,...
Wiley, 2010. - 623 p. In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease...
Wiley, 2014. - 476 p. - In contrast to previous texts focusing on either computational, structural or synthetic methods, this one–of–a–kind guide integrates all three skill sets for a complete picture of contemporary structure–based design. As a result, this practical book demonstrates how to develop a high–affinity ligand with drug–like properties for any given drug target for...
Wiley, 2005. — 644 p. 3Li Lithium Metallotherapeutics 5B Boron Compounds as Therapeutic Drugs 12Mg The Role of Magnesium as a Metallotherapeutic Drug 13Al Aluminum Metallotherapeutics 14Si Biological Activity of Organosilicon Compounds 20Ca The Role of Calcium as a Metallotherapeutic Drug 22Ti Anti-tumor Titanium Drugs 23V Insulin-Mimetic Vanadium-Containing Compounds 25Mn...
Wiley VCH, 2018. — 777 p. — (Methods and Principles in Medicinal Chemistry. Volume 73). This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to...
CRC Press, 2018. - 311 p. Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume III is devoted to the growing variety of...
Wiley-VCH, 2009. - 244 p. By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches...
Springer, 2017. — 170 p. This book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary application of drug-designing methodologies to inspire others to further expand the utility of this field in other...
William Andrew, 2018. — 814 p. — (Pharmaceutical Nanotechnology). — ISBN: 978-0-12-813689-8 This book covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of...
Wiley-VCH, 1998. — 159 p. Writing or editing a book about a rapidly evolving area of science is a challenge. Doing this while being involved in real projects every day is even more of a challenge. And changing location and assignment during this exercise (which is true for both editors) adds further hurdles. We are thus particularly glad to now present a series of real-life...
Wiley-VCH, 1998. — 159 p. Writing or editing a book about a rapidly evolving area of science is a challenge. Doing this while being involved in real projects every day is even more of a challenge. And changing location and assignment during this exercise (which is true for both editors) adds further hurdles. We are thus particularly glad to now present a series of real-life...
Springer Vienna, 2013. — 478 p. Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to...
CRC Press, 2023. — 263 p. — (Current Trends in Antimicrobial Research). — ISBN: 9781032215532. The need for state-of-the-art antimicrobial agents is greater than ever because of the development of multidrug resistance in communal pathogens, the rapid rise of new infections, and the potential for the use of multidrug-resistant agents in biological protection. Although the need...
Academic Press, 2020. — 506 p. — ISBN: 978-0-12-818168-3. This book presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as...
CRC Press, 2015. — 152 p. — ISBN: 1466579986. The biopharmaceutical industry has entered an era of unprecedented change and challenge, characterized by increasing pricing pressures, rising rates of attrition in the product development lifecycle, and decreasing scientific innovation. The most successful products are losing patent protection, and pipelines have been unable to...
Wiley-VCH, 2018. — 522 p. — ISBN: 978-3-527-67440-4. The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also...
Wiley-VCH, 2014. — 654 p. — ePDF ISBN: 978-3-527-67655-2 The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future...
RSC, 2003. — 149 p. The Classes of Natural Product and Their Isolation The Characterization and Determination of the Carbon Skeleton of a Natural Product The Location of the Functional Groups and the Molecular Stereochemistry Some Ezamples of Structure Elucidation The Biosynthesis of Secondary Metabolites Further Reading Answers to Problems
Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany. – 2013, 350 p. – ISBN: 3527329846. Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine....
Taylor & Francis Group, 2014. - 252 p. - Theory of Drug Development presents a formal quantitative framework for understanding drug development that goes beyond simply describing the properties of the statistics in individual studies. It examines the drug development process from the perspectives of drug companies and regulatory agencies. By quantifying various ideas underlying...
Royal Society of Chemistry, 2015. — 314 p. Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the...
Authors not specified. FDA, 2002. - 38 p. This guidance makes recommendations to sponsors of investigational new drugs on the parameters that should be routinely assessed in toxicology studies to determine effects of a drug on immune function, when additional immunotoxicity studies should be conducted, and when additional mechanistic information could help characterize the...
Wiley, 2022. — 384 p. — ISBN: 978-1-394-16723-4. The use of machine learning algorithms in drug discovery has accelerated in recent years and this book provides an in-depth overview of the still-evolving field. The objective of this book is to bring together several chapters that function as an overview of the use of machine learning and artificial intelligence applied to drug...
Springer, 2015. — 710 p. This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These...
London: Royal Society of Chemistry, 2017. — 347 p. The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug...
Springer, 2013. - 331 p. - This book will illustrate the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text will highlight recent developments from these disciplines that have delivered drugs, clinical candidates or significantly...
Springer, 2018. - 66 p. The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug...
Wiley, 2011. - 468 p. A complete, one-stop reference to real-world antiviral drug discovery and development. The field of antiviral drugs continues to evolve at a fast pace in response to new virus discoveries and development of viral resistance to existing therapies. This book provides case histories and arms both basic and industrial pharmaceutical researchers with practical...
Wiley-Blackwell, 2018. — 476 p. — ISBN: 978-1-118-80128-4. A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current...
Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, 2015. — 361 p. — (Methods and Principles in Medicinal Chemistry. Volume 65) — ISBN: 352733582X This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the...
Academic Press, 2018. — 470 p. — ISBN: 978-0-12-812218-1. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to...
Wiley-Scrivener, 2024. — 670 p. The book is a comprehensive guide that explores the use of Artificial Intelligence (AI) and Machine Learning (ML) in drug discovery and development covering a range of topics, including the use of molecular modeling, docking, identifying targets, selecting compounds, and optimizing drugs. The intersection of Artificial Intelligence and Machine...
CRC Press, 2010. — 371 p. — ISBN: 1420073494 Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D...
Springer, 2013. — 918 p. Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of...
American Chemical Society, 2012. - 317 p. - During the past several years, it has become increasingly clear that carbohydrates, which can be targeted to specific diseases, represent a whole new dimension in drug design. Characterized by a variety of terms - specific recognition, lectins, and molecular diversity, just to cite a few - this new dimension based on carbohydrates...
Springer, 2016. — 146 p. The book describes the individual steps necessary for biomacromolecular fragments analysis, as well as a list of essential software tools. For each step, it also shows corresponding web-based tools in detail and provides practical examples of their use. All tools and databases mentioned in the examples are available free of charge, platform-independent,...
Wiley, 2013. — 465 p. Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading...
New York: Ellis Horwood. – 2005. – 150 p. The Department of Pharmaceutical-Medicinal Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, organizes, every other year, a graduate seminar in advanced medicinal chemistry, with international participation, in Thessaloniki. The purpose of this seminar is to help young and ambitious pharmaceutical scientists in...
Wiley-VCH, 2012. — 1738 p. In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and...
New York: Taylor & Francis. – 2006. – 301 p. (Drugs and the Pharmaceutical Sciences: A Series of Textbooks and Monographs 161) Arguably the most difficult aspect of drug development, once proof-of-concept is achieved for a novel mechanism, is defining the right dose. Indeed, the question rapidly expands to right for whom? An individual? A population? A specific disease? A...
Springer, 2008. — 383 p. In the last two decades, the discipline of biopharmaceutics has undergone considerable advances, particularly with regard to bioavailability and bioequivalence as they relate to product quality and regulatory standards of approval. Textbooks in the field have not been able to keep up with the growth of current and emerging applications of regulatory...
IOS Press, 2008. — 141 p. — (Solvay Pharmaceuticals Conferences. Volume 9) — ISBN: 1586039490 The scope of this book is that the pharmaceutical industry must change the way it operates. The editors of this book feel that the current business model is economically unsustainable and incapable to meet expectations of modern society. The number of novel medications in the global...
Taylor & Francis Group, LLC., 2008. – 256 p. – ISBN: 0849372682. The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. Introduction and Review....
CRC Press, 2022. — 483 p. — ISBN: 978-1-032-28842-0. The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and...
Wiley-VCH Verlag GmbH, 2006. - 375 p. A Personal Foreword. Pharmacophores: Historical Perspective and Viewpoint from a Medicinal Chemist. Pharmacophore Approaches. Pharmacophore Model Generation Software Tools. Alignment-free Pharmacophore Patterns – A Correlation-vector Approach. Feature Trees: Theory and Applications from Large-scale Virtual Screening to Data Analysis....
Marcel Dekker, INC. New York Basel. 1998. - 501 p. This useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development. Shows how to overcome pharmaceutical, technological,...
Oxford University Press, 2006. — 310 p. This is a book on the history of drug discovery. More important, this is a book about drug discoverers that highlights their intellectual splendor, as well as their human frailty. In preparing this manuscript, I have had the great fortune to communicate with some scientists who played pivotal roles in discovering the drugs we use. Cancer...
Second Edition. – Boca Raton: CRC Press. – 2008. – 685 p. This book has its origin in a training course, “The Role of Drug Solubility in Formulation Development,” offered by the American Association of Pharmaceutical Scientists, 6 years ago in Chicago. The course was designed to help young pharmaceutical scientists and pharmacy graduate students solve problems often encountered...
3rd Edition. — Boca Raton, USA: CRC Press, Taylor & Francis Group, 2018. — 757 p. — ISNB-13 978-1-4987-2941-3. Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can...
Royal Society of Chemistry, 2012, 498 p., ISBN: 978-1-84973-166-9 This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems...
Wiley, 2010. — 879 p. The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied...
Apple Academic Press Inc., 2021. — 322 p. — ISBN: 978-1-00305-750-5. Natural products that have both plant growth regulatory properties and pharmaceutical properties are examined in this book. This is the first and most up-to-date text linking agrochemistry and pharmaceutical chemistry in an easy-to-read presentation for practitioners in both fields. Due to the intense and...
New York: Marcel Dekker, 2004. — 348 p. Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods - a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during...
New York, Marcel Dekker, Inc., 2002. — 335 p. — ISBN: 0-8247-0804-0. Surfactant and polymer systems play an important role in modern drug delivery, where they may allow control of the drug release rate, enhance effective drug solubility, minimize drug degradation, contribute to reduced drug toxicity, and facilitate control of drug uptake. In all, they contribute significantly...
Elsevier, 2018. — 760 p. — ISBN: 978-0-08-102081-4. This book provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active...
Woodhead Publishing, 2015. - 260 p. In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in...
Springer, 2018. - 455 p. This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and...
Cambridge University Press, 2010. - 287 p. Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR,...
Woodhead Publishing, 2017. — 538 p. — (Woodhead Publishing Series in Biomedicine). — ISBN: 978-0-08-100625-2. This book thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm...
CRC Press, 2018. - 315 p. This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal,...
Smithers Rapra Technology, 2014. — 576 p. Use of polymers has become indispensable in the field of drug delivery. Polymers play a crucial role in modulating drug delivery to exploit maximum therapeutic benefits and have been fundamental in the successful development of several novel drug delivery systems that are now available. This book provides details of the applications of...
Springer, 2019. - 414 p. This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking,...
Humana Press Inc. 2004. — 372 p. ISBN: 158829515X Although it is relatively easy to determine the efficacy of a new drug, it is difficult to establish its safety when administered to millions of patients with multifaceted diseases, co-morbidities, sensitivities, and multiple drug use. In Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug...
McGraw-Hill, 2011. — 240 p. This definitive text provides in-depth information on computer-assisted techniques for discovering, designing, and optimizing new, effective, and safe drugs. Computer-Aided Drug Design and Delivery Systems offers objective and quantitative data on the use and delivery of drugs in humans. Enabling technologies such as bioinformatics, pharmacokinetics,...
4th Edition. — CRC Press, Taylor & Francis Group, 2019. — 1145 p. — ISBN13: 978-1-4987-1914-8. Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacturing of parenteral dosage forms, effectively balancing theoretical considerations with practical aspects of their development. Previously published as a three-volume set, all...
3rd edition. — Informa Healthcare, 2010. — 420 p. This three-volume set of Pharmaceutical Dosage Forms: Parenteral Medications is an authoritative, comprehensive reference work on the formulation and manufacture of parenteral dosage forms, effectively balancing theoretical considerations with the practical aspects of their development. As such, it is recommended for scientists...
3rd edition. — Wiley-Blackwell, 2015. — 545 p. — ISBN: 978-1-118-90727-6. The third edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the...
Wiley, 2017. — 564 p. — ISBN: 9781119060680. Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies...
Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2008. – 522 p. –ISBN: 3527318720. Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR....
Springer, 2006. Ferrari M. (ed.). BioMEMS and Biomedical Nanotechnology. Volume I: Biological and Biomedical Nanotechnology. Chapter 2. Factors Affecting Release Rates Recent Applications of Controlled Release Microspheres Fabrication of Polymer Micro- and Nanoparticles Techniques for Fabricating Uniform Microspheres Techniques for Fabricating Uniform Core-Shell Microparticles...
Royal Society of Chemistry, 2012, 438 p., ISBN: 978-1-84973-192-8 There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of...
2nd edition. — Humana Press, 2010. — 516 p. This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
The Royal Society of Chemistry, 2015. — 312 p. — (RSC Drug Discovery Series 46). — eISBN: 978-1-78262-265-9. The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to...
Wiley, 2015. — 439 p. By integrating knowledge from pharmacology, microbiology, molecular medicine, and engineering, researchers from Europe, the U.S. and Asia cover a broad spectrum of current and potential antimicrobial medications and treatments. The result is a comprehensive survey ranging from small-molecule antibiotics to antimicrobial peptides and their engineered...
Woodhead Publishing, 2013. - 436 p. - The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this;...
Wiley-VCH GmbH, 2024. — 730 p. — ISBN: 978-3-527-35374-3, 978-3-527-35375-0. Computational Drug Discovery: Methods and Applications (2-volume set) covers a wide range of cutting-edge computational technologies and computational chemistry methods that are transforming drug discovery. The book delves into recent advances, particularly focusing on artificial intelligence (AI) and...
Apple Academic Press, 2021. — 363 p. This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous...
NIDA Research Monograph Series No 79, A RAUS Review Report, 1987. – 216 p. Structure-Activity Relationships in Cannabinoids: An Overview Stereochemical Requirements for Cannabimimetic Activity Structure-Activity Relationships of Tricyclic and None lass ica I Bicyclic Cannabinoids Structure-Anticonvulsant Activity Relationships of Cannabidiol Analogs Anticonvulsant and...
ITexLi, 2024. — 160 p. — ISBN: 0850142326 9780850142327 0850142318 9780850142310 0850142334 9780850142334. This book provides a detailed overview covering all aspects of drug development, from synthesis and manufacturing to delivery strategies, and ensuring a thorough understanding of the field. This book will show how new drugs are made. The chapters give inside information on...
John Wiley & Sons, 2011. — 528 p. — ISBN: 978-3-527-32669-3 Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people...
CRC Press, 2008. - 380 p. - An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to...
Humana Press, 2010. — 297 p. Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead...
Humana Press, 2019. - 563 p. This detailed book showcases recent advances in computational design of multi-target drug candidates involving various ligand and structure-based strategies. Different chem-bioinformatic modeling strategies that can be applied for design of multi-target drugs as well as important databases and web servers in connection with multi-target drug design...
ITexLi, 2023. — 206 p. — ISBN: 1837687773 9781837687770 1837687765 9781837687763 1837687781 9781837687787. This volume delivers up-to-date information on the identification of newer uses, molecular mechanisms, and novel targets of existing drug candidates through the application of various experimental, biophysical, and computational approaches and techniques. The book...
CRC Press / Apple Academic Press, 2024. — 294 p. — ISBN: 978-1-77491-277-5. This new volume presents exciting recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases, including microbial infections, parasitic diseases, brain disorders, and cancer. Drug...
InTech, 2011. - 654 p. This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are...
Instituto de Quґımica, Universidade Federal do Rio Grande do Sul, 2003. — 4 p. The (+/−)-threo-methylphenidate hydrochloride (Ritalin), is an indirect catecholamine agonist,1 and is the drug treatment of choice for the attention deficit/ hyperactivity disorder (AD/HD),2 one of the most common behavioral disorders of childhood which affects 5–10% of the general population.3 The...
Springer, 2017. — 318 p. — (Methods in Molecular Biology). — ISBN: 978-1-4939-6561-8. miRNA Targeting Drugs: The Next Blockbusters? Functional Analysis of miRNAs Using the DIANA Tools Online Suite. Non-Nucleotide Modification of Anti-miRNA Oligonucleotides. Quantification of Oligonucleotide Association with miRNA–Argonaute Complexes In Vitro. Determination of Anti-miR...
Wiley-VCH, 2013. — 578 p. — ISBN: 3527334610. Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic–chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline...
Wiley, 2002. - 369 p. - Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's...
ExLi4EvA., 2016. – 397 p. – ISBN: 9535122479. This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. The readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. This reference discusses advances in the design,...
InTech, 2012. - 510 p. This reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals. This book collects reviews and original articles from...
Apple Academic Press, 2019. - 448 p. With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery. The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the...
Elsevier, 2020. — 239 p. — ISBN: 978-0-12-817778-5. This book reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced...
Springer, 2018. — 332 p. — ISBN: 9811307725. This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors....
ITexLi, 2023. — 307 p. — ISBN: 1837684723 9781837684724 1837684715 9781837684717 1837684731 9781837684731. This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and...
Springer, 2012. - 607 p. This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly...
3rd ed. — Academic Press, 2015. — 521 p. in color. — ISBN: 9780123820303. The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many...
Article. Published in The American Journal of Clinical Nutrition, 1993;58:622-626 The present investigation was undertaken to assess the efficacy of oral iron supplementation during pregnancy by using a gastric delivery system (GDS). Three hundred seventy-six pregnant women between 16 and 35 y of age and 14 and 22 wk gestation were selected if mild anemia was present...
Article. – Experimental and Molecular Pathology. - 2009. - Vol. 86.—P. 215–223. Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the nanometer size range. These nano-sized objects, e.g., nanoparticles, take on novel properties and functions that differ markedly from those seen...
Wiley-VCH, 2019. — 506 p. This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything...
Wiley, 2009. — 310 p. — (Methods and Principles in Medicinal Chemistry 42). Fueled by the expertise of a team of international specialist authors, this first reference on the booming topic covers everything a drug researcher needs to know about targeting epigenetic mechanisms of disease. The first part of the book surveys current methodologies for finding and validating drug...
Second edition. — Informa Healthcare, 2006. — 648 p. — ISBN: 9780849327797. The book presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This new addition updates the scientific advances in new drug discovery and development for areas such as...
2th ed. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2006. — 207 p. ISBN13: 978-3-527-31368-6. ISBN10: 3-527-31368-0. In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new...
John Wiley and Sons, 2005. — 483 p. Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on...
Thoth Press, 2005. - 259 p. ISBN: 0966312864 Love Drugs is a sequel to Amphetamine Syntheses (2002) Expanded coverage of the synthesis of MDMA and other empathogens and stimulants. Expanding the chemistry of empathogens. MDMA from scratch. Small and large scale production is described in detail. Hot new formulas abound. Piperonyl-acetone from both safrol and isosafrol. Multiple...
CRC Press, 2016. — 335 p. Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties. Written by an international group of...
The Royal Society of Chemistry, 2017. — 586 p. With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based...
Fifth Edition. — CRC Press, 2017. — 527 p. — ISBN: 978-1-4987-0278-2. Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and...
Springer, 2017. — 410 p. — ISBN10: 4431565248, 13 978-4431565246. This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients...
Springer, 2017. — 496 p. — ISBN10: 4431565248, 13 978-4431565246. This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients...
Wiley-VCH, 2019. — 376 p. — ISBN: 978-3-527-34304-1 Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization's list of neglected tropical diseases. The authors - all are experts on the topic - address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world's...
InTech, 2012. - 100 p. ISBN: 9535103080 9789535103080. This volume describes a group of virtual screening methods and techniques that are used currently in modern drug discovery. Virtual Screening is directed to those interested in the different aspects of drug design that include academicians (pharmacists, chemists), and scientists at pharmaceutical companies. The first...
Springer New York, 2010. — 248 p. This book emphasizes dose selection issues from a statistical point of view. It presentsstatisticalapplicationsinthedesignandanalysisofdose–responsestudies. The importance of this subject can be found from the International Conference on Harmonization (ICH) E4 Guidance document. Establishing the dose–response relationship is one of the most...
Wiley, 2018. — 433 p. — ISBN: 978-1-118-69621-7. An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical...
Springer, 2008. - 484 p. - Various pharmaceutical nanocarriers, such as nanospheres, nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established...
Wiley, 2006. - 488 p. - Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related...
Springer, 2017. — 154 p. — ISBN: 978-3-319-59503-0. Delivery of drugs through skin has been an attractive area for research and for pharmaceutical companies as it can offer larger therapeutic window compared to systemic delivery. Dermal drug development started back in the 1950s with corticosteroids as, despite impressive efficacy, corticosteroids use was limited because of the...
2nd Edition. Springer. 2010. — 280 p. ISBN: 1441964177 New Drug Development: Second Edition provides an overview of the design concepts and statistical practices involved in therapeutic drug development. This wide spectrum of activities begins with identifying a potentially useful drug candidate that can perhaps be used in the treatment or prevention of a condition of clinical...
Wiley, 2007. — 298 p. New Drug Development The Regulatory Environment for New Drug Development Drug Discovery and Nonclinical Research Drug Discovery Nonclinical Research Design, Methodology, and Analysis Design and Methodology in Clinical Trials Statistical Analysis Statistical Significance: Employment of Hypothesis Testing Clinical Significance: Employment of Confidence...
Wiley, 2014. - 453 p. - Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, "Physicochemical and Biomimetic Properties in Drug Discovery" encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in...
VCH Publishers, 2008. — 369 p. The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices in the planning of syntheses, and describes techniques for analyzing biological...
Springer Science+Business Media, 2015. — 167 p. Series: Advances in Experimental Medicine and Biology. Vol. 863. This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common...
Springer, 2009. -663. - The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be...
2nd ed. — Wiley, 2016. — 738 p. — (Drug Discovery and Development). — ISBN: 1118833368, 9781118833360 An indispensable tool for those working at the front lines of new drug development The development of effective delivery systems is crucial to taking a drug from the discovery and development stages to successful clinical use. The advances of recent years in the pharmaceutical...
Wiley, 2005. - 461 p. - An indispensable tool for those working at the front lines of new drug development. Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial...
Taylor & Francis Group, 2012. - 396 p. - Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that...
CRC Press, 2016. — 334 p. This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal...
Informa Healthcare, USA, Inc., 2008. — 532 p. — (Drugs and the pharmaceutical sciences 172) — ISBN: 1420043870. This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also...
Wiley, 2012. - 393 p. - Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are...
Elsevier, 2014. -194 p. - Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical...
Wiley, 2018. — 558 p. — ISBN: 978-1-118-68633-1. A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews...
John Wiley & Sons, Inc. 2009. — 307 p. For students interested in pursuing a career in the drug design field, this text is intended to give an ideal starting point for their studies. The text assumes a solid background in chemistry, a basic understanding of biochemistry, and nly minimal previous exposure to computational chemistry. Researchers already employed in the drug...
Wiley, 2016. — 457 p. The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation...
Springer, 2011. — 396 p. — ISBN: 978-1-4419-9901-6. The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key...
Totowa, NJ.: Humana Press Inc. 2005. — 382 p. Fundamental Issues Related to Natural Product-based Drug Delivery Natural Products and Drug Discovery. Arnold L. Demain and Lixin Zhang Strategies Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products. Lixin Zhang Automated Analyses of Hplc profiles of Microbial Extracts: A new Tool for Drug Discovery...
New York: Springer, 2016. - 290 p. Features practical, hands-on instruction for the use of CADD systems Includes tips from experts in the field to ensure successful implementation Focuses on the vital early stages of the drug discovery process This detailed volume examines computer-aided drug discovery (CADD), a crucial component of modern drug discovery programs that is widely...
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