Humana Press, 1999. — 404 p. In this volume Andrew Baker and a noted panel of expert investigators describe today's most powerful molecular methods for investigating the pathogenesis of vascular disease. These detailed, easy-to-follow techniques range from methods that have been used successfully to identify specific mutations involved in cardiovascular disorders, to those for...
Springer, 2013. — 820 p. Omics for Personalized Medicine will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. General Aspects...
Springer, 2017. — 261 p. — (Current Topics in Microbiology and Immunology). — ISBN10: 3319588915, 13 978-3319588919. This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and...
Springer, 2017. — 316 p. — (Current Topics in Microbiology and Immunology). — ISBN10: 3319588915, 13 978-3319588919. This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and...
Academic Press, 2018. — 389 p. — ISBN: 978-0-12-814393-3. Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals...
Wiley, 2003. — 286 p. This introductory reference provides a practical, concise summary of everything a physician needs to know about genomics and emerging technologies. Through extensive illustrative examples, this book offers a clear and concise starting point to understanding how medicine has been, and will be, transformed by genomics and bioinformatics. Beginning with a...
Cambridge University Press, 2018. — 229 p. — ISBN: 978-0-521-13298-5. Mitochondrial disorders are a highly diverse group of conditions that can affect almost every major system in the human body, often mimicking common disorders. This clinical variety often results in prolonged and often dangerous, diagnostic delays. This textbook provides a practical framework, to enable rapid...
Springer, 2017. — 105 p. — (Springer Theses). — ISBN10: 3319585177, ISBN13: 978-3319585178. This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases. Previous...
Boca Raton: CRC Press, 2007. — 357 p. Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently...
Academic Press, 2020. — 571 p. — ISBN: 978-0-12-819178-1. This book addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about...
Academic Press, 2015. — 398 p. Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids...
Springer, 2018. — 263 p. — (Topics in Medicinal Chemistry). — ISBN10: 3319885464. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs....
Humana Press, 2001. — 259 p. At a time of rising concern about drug resistance and falling output of new antibacterial compounds, antibiotic research has once again returned to the forefront of medical science. In Antibiotic Resistance: Methods and Protocols, Stephen Gillespie and a panel of leading clinical and diagnostic microbiologists describe a series of detailed molecular...
3rd edition. — Humana Press, 2017. — 169 p. This third edition provides a wide range of different technologies, ranging from conventional growth basic techniques, application of molecular biology, development of resistance mutations, and diagnosis and monitoring treatment response. New and updated chapters cover techniques from the microscopic scale to whole animal models....
Springer International Publishing AG, 2017. — 379 p. — (Plant Genetics and Genomics: Crops and Models 21) — ISBN: 3319493272. Marking the change in focus of tree genomics from single species to comparative approaches, this book covers biological, genomic, and evolutionary aspects of angiosperm trees that provide information and perspectives to support researchers broadening the...
Springer, 2008. — 446 p. — ISBN: 978-1-4020-6713-6 Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial...
Springer, 2012. — 428 p. — ISBN: 978-1-4614-2169-6. This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today’s...
Humana, 2012. — 254 p. Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as...
Workshop Summary. — National Academies Press, 2013. — 428 p. Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was...
Humana Press, 1998. — 1144 p. This is the first major textbook of molecular medicine to integrate the newest findings from cell and molecular biology with the basic principles of internal medicine. J. Larry Jameson, MD and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide...
Humana Press, 1999. — 577 p. Series: Methods in Molecular Medicine, № 23 In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety of...
Humana Press, 2004. — 344 p. Molecular biology has transformed the field of pathology by providing new insights into human diseases and new tools for the diagnosis and classification of disease. In Principles of Molecular Pathology, Anthony Killeen, md, Ph.D., offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical...
Willey-Liss, Inc, 2001. — 393 p. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation,...
Academic Press, 2020. — 581 p. — ISBN: 978-0-12-809356-6. This book presents the latest scientific advances in molecular and cellular biology, including the development of new and effective drug and biological therapies and diagnostic methods. The book provides medical and biomedical students and researchers with a clear and clinically relevant understanding on the molecular...
Humana Press, 2014. — 278 p. In this book expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target. These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. We are convinced that these methods will help researchers...
Springer, 2018. — 532 p. This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume,...
Apple Academic Press, 2014. — 456 p. This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics....
Taylor & Francis, 2003. — 346 p. Pore-forming proteins and peptides are ubiquitous in living organisms. They play a central role in bacterial pathogenesis, immune response, venomous attack and innate immunity, by which means they are used to attack and eliminate other organisms. They have the extraordinary property of having two stable structural states. One corresponds to the...
Springer, 1996. — 321 p. Joseph E. Alouf "The empirical basis of objective science has thus nothing 'abso lute' about it. Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we...
2nd ed. — John Wiley & Sons, 2005. — 659 p. An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases was written for advanced level undergraduate courses, introductory graduate level courses, and basic medical school courses on human genetics. The text examines how human genes are discovered and, once a gene is known, how the defective versions(s) causes a...
Academic Press, 2019. — 119 p. — ISBN: 978-0-12-817006-9. This book is an applied, holistic resource that addresses the evolving and multidisciplinary area of mitochondrial disease. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases. Three all-inclusive sections examine the...
Springer, 2012. - 574 p. Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence...
2nd Edition. — Humana Press, 2006. — 1296 p. This fully updated and expanded edition of the much-acclaimed Principles of Molecular Medicine provides an integrated survey of the basic principles of internal medicine, in light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. In addition to fully revised...
Springer, 2017. — 163 p. — (Advances and Controversies in Hematopoietic Transplantation and Cell Therapy). — ISBN10: 3319589482, 13 978-3319589480. This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The...
Springer, 2017. — 186 p. — (Advances and Controversies in Hematopoietic Transplantation and Cell Therapy). — ISBN10: 3319589482, 13 978-3319589480. This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The...
Springer, 2017. — 161 p. — (Current Human Cell Research and Applications). — ISBN10: 9811064687, 13 978-9811064685. This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical...
Springer, 2017. — 207 p. — (Current Human Cell Research and Applications). — ISBN10: 9811064687, 13 978-9811064685. This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical...
Humana Press, 2015. — 496 p. The book provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for...
Churchill Livingstone, 2006. — 274 p. This title is directed primarily towards health care professionals outside of the United States. It starts with the origin of life and ends with the mechanisms that make muscles adapt to different forms of training. In between, it considers how evidence has been obtained about the extent of genetic influence on human capacities, how muscles...
4th Edition. — Elsevier, 2012. — 333 p. Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and...
Springer, 2017. — 180 p. This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of...
Springer, 2001. — 171 p. Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which...
Wiley-VCH, 2003. — 408 p. This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The...
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