Buschmann H., Christoph T. e.a. (ed.) Analgesics. From Chemistry and Pharmacology to Clinical Application

Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 2002. 605 p.This book deals with established analgesics as well as with new chemical entities for established and new targets. Compounds are classified with respect to their physiological target. In every case the structural formula is given as well as further information e.g. on the pharmacological profile, synthetic routes or major metabolites if important. In addition, structure-activity relationships are discussed if available. Consequently following this scheme, a huge number of compounds is evaluated and a clear picture especially of pain research in the industrial setting is constructed.
Based on the snapshot-like collection of information in this book the cyclooxygenase and the opioid systems are still the most attractive targets and ligands acting on this system are still not surpassed by ligands of other targets. It is also clear, however, that we are at the beginning of an era of promising new approaches to pain therapy. The future will show which targets will survive the race for the best therapy.
The book presented here will be highly valuable for advanced students in pharmaceutical and medicinal chemistry as well as for scientists in the field of chemistry, biochemistry and pharmacology in industrial and academic research.What Is Pain?
Cyclooxygenase Inhibition: From NSAIDS to Selective COX-2 Inhibitors (part 1)
Cyclooxygenase Inhibition: From NSAIDS to Selective COX-2 Inhibitors (part 2)
Cyclooxygenase Inhibition: From NSAIDS to Selective COX-2 Inhibitors (part 3)
Opioids: 3.1 Introduction
Opioids: 3.2 Opioid Pepties
Opioids: 3.3 Synthetic Opioids
Opioids: 3.4 Opioids with Clinical Relevance
Opioids: 3.5 Drug Delivery Systems for Opioids
NA and 5-HT Reuptake Inhibitors and α2 Agonists
Gabapentin and Gabapentinoids
Voltage-Gated Ion Channels: 6.1 Sodium Channels
Voltage-Gated Ion Channels: 6.2 Potassium Channels
Voltage-Gated Ion Channels: 6.3 Calcium Channels
Glutamate Receptors: 7.1 Metabotropic Glutamate Receptors
Glutamate Receptors: 7.2 NMDA Receptors
Glutamate Receptors: 7.3 AMPA and Kainate Receptors
Acetylcholine Receptors: 8.1 Nicotinic Acetylcholine Receptors
Acetylcholine Receptors: 8.2 Muscarinic Acetylcholine Receptors
Further Opioid Receptors: 9.1 The δ-Opiod Receptor
Further Opioid Receptors: 9.2 Opioid-Receptor-Like 1 (ORL1)
Adenosine
P2 Receptors
Natural and Synthetic Cannabinoids
Vanilloids and the VR1 Receptor
Substance P/NK1 Receptors
CGRP1-Receptor Antagonists
Nitric Oxide: Potential of NO Donors and NO Synthase Inhibitors for the Treatment of Pain
The Future of Pain Management