Ramsden J.J. Biomedical Surfaces

Artech House, Boston, 2008. — 155 p. — ISBN: 1596932406Engineering in Medicine & BiologyHere's the first state-of-the-art design reference on artificial implant surfaces. It takes you to the cutting-edge of efforts to understand and control the constant interactions taking place between biomaterials and biological media. The book explores processes and surface modifications that occur in various bio/non bio interfaces, and pres the latest performance-enhancing design, materials selection, and manufacturing guidance including nanotechnology breakthroughs that are ushering in a new age of biomaterial design and applications. After an extensive discussion of biomedical surfaces attributes, the book addresses design issues that arise where materials and biofluids interface and the supion or selective adsorption of biomacromolecules is a key objective. Implant lubrication and wear issues are covered, including adsorption of lubricants on surfaces and the tribology of the surfaces themselves. The book explores interaction issues crucial to predicting biomaterial interactions with body tissues, including protein adsorption and desorption processes, immune cell response, the assimilation and interaction of cells like osteocytes, and bacterial infection
risks, and includes a chapter on biomedical surfaces manufacturing which emphasizes practical design issues. The volume also examines emerging nano-engineered materials including smart surfaces that are responsive to host cells and tissues, as well as novel drug delivery surfaces developed with nano- and microtechnologies. Complete with techniques for measuring surface properties, this well-illustrated resource helps you design or select implants that deliver ever-higher levels of performance and durability.The adsorption and desorption of biomacromolecules
Elementary physico-chemical considerations
Monolayer adsorption
Desorption
Adsorbed protein exchange
Multilayer adsorption
Multicomponent adsorption
Adsorption onto heterogeneous surfaces
Further reading
Chemical and physical attributes of biomedical surfaces
Interaction energetics
Wettability
Morphology
Chemistry
Biodegradability
Further reading
Biofluid compatibility
Haemocompatibility
Urine compatibility
Lachrymal secretions
Buccal secretions
Bioanalytical surfaces
Further reading
Cell and tissue interaction with surfaces
Principles of eucaryotic cell architecture
Cell adhesion
The adhesion of cells to artificial surfaces
Principles of tissue architecture
Assimilation
Bacterial infection of implants
Further reading
Lubrication and wear
Fundamentals of tribology
Friction in hip endoprostheses
Possible physiological effects of particles released as a result of wear
Further reading
Surface generation, engineering and coating
Machining
Surface engineering
Surface coatings
Further reading
The metrology of biomedical surfaces
Energetics
Morphology
Dynamical structure measurements
Chemical surface analysis
Cytometry
Quantifying biocompatibility
Further reading
Prospects for smart and nano materials
The nature of responsiveness
Bioactive coatings
Carbon nanotubes in biomedical surfaces
A complexity sciences perspective for biomaterials design
Further reading