Rehm H.J., Reed G. (eds.) Biotechnology: Recombinant Proteins Monoclonal Antibodies Therapeutic Genes

Second edition. Volume 05a - Wiley, John & Sons, 1999. - 580 p.
A Multi Volume Comprehensive Treatise. Edited by H. J. Rehm and G. Reed in cooperation with A. Ptihler and Stadler. This book was carefully1y produced. However, authors, editors and publisher do not warrant the information contained therein to be free of enors. Readers are advised tokeepinmind thatstatements, data, i1lustrations, procedural details or other items tray inadvertently be inaccurate.Contents
Structure and Function of Proteins.
Types and Function of Proteins
Sequence and Structure of Proteins
Protein Interactions
Recombinant Proteins.
In vitro Folding of Inclusion Body Proteins on an Industrial Scale
Medical Applications of Recombinant Proteins in Humans and Animals
Enzymes for Industrial Applications
Monoclonal Antibodies.
Antibody Engineering and Expression
Manufacture of Therapeutic Antibodies
Use of Antibodies for Immuno-purification
Preclinical Testing of Antibodies: Pharmacology, Kinetics, and Immunogenicity
Preclinical Testing of Antibodies: Safety Aspects
Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview
Case Studies.
Antibodies for Sepsis: Some Lessons Learnt
An Engineered Human Antibody for Chronic Therapy: CDP571
Antibody Targeted Chemotherapy
ReoPro Clinical Development: A Case Study
Gene Therapy.
Overview of Gene Therapy
Viral Vectors for Gene Therapy
Non-Viral Vectors for Gene Therapy
Issues for Large-Scale Plasmid DNA Manufacturing
Gene Therapy for HIV Infection
Regulatory and Economic Aspects.
Regulation of Antibodies and Recombinant Proteins
Regulation of Human Gene Therapy
Economic Considerations