Geacintov N.E., Broyde S. (Eds.) The Chemical Biology of DNA Damage

Wiley, 2010. - 473 p. - Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.
A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.Chemistry and Biology of DNA Lesions.
Introduction and Perspectives on the Chemistry and Biology of DNA Damage
Chemistry of Inflammation and DNA Damage: Biological Impact of Reactive Nitrogen Species
Oxidatively Generated Damage to Isolated and Cellular
Role of Free Radical Reactions in the Formation of DNA Damage
DNA Damage Caused by Endogenously Generated Products of Oxidative Stress
Polycyclic Aromatic Hydrocarbons: Multiple Metabolic Pathways and the DNA Lesions Formed
Aromatic Amines and Heterocyclic Aromatic Amines: From Tobacco Smoke to Food Mutagens.
Genotoxic Estrogen Pathway: Endogenous And Equine Estrogen Hormone Replacement Theory
New Frontiers and Challenges: Understanding Structure-Function Relationships and Biological Activity.
Interstrand DNA Cross-Linking 1,N2-Deoxyguanosine Adducts Derived From a, ß-Unsatruated Aldehydes: Structure-Function Relationships
Structure-Function Characteristics of Aromatic Amine-DNA Adducts
Mechanisms of Base Excision Repair and Nucleotide Excision Repair
Recognition and Removal of Bulky DNA Lesions by the Nucleotide Excision Repait System
Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function
Elucidating Structure-Function Relationships in Bulky DNA Lesions: From Solution Structures to Polymerases
Translesion Synthesis and Mutagenic Pathways in Escherichia Coli Cells
Insight into the Molecular Mechanism of Translesion DNA Synthesis in Human Cells Using Probes with Chemically Defined DNA Lesions
DNA Damage and Transciption Elongation: Consequences and RNA