Drug Discovery Today 2012 v.17 №17-18

London, UK.: Elsevier. — 140 p.Since its launch in 1996, Drug Discovery Today has been at the cutting edge of the science underpinning drug discovery and development. Drug Discovery Today delivers highly current reviews to the readers, not only addressing the rapid scientific developments in drug discovery associated technologies, but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed.Contents:
Foundation.
The future of antibodies as cancer drugs.
Janice M. Reichert and Eugen Dhimolea.
Keynote.
Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.
David Borsook, Jaymin Upadhyay, Michael Klimas, Adam J. Schwarz, Alexandre Coimbra, Richard Baumgartner, Edward George, William Z. Potter, Thomas Large, David Bleakman, Jeffrey Evelhoch, Smriti Iyengar, Lino Becerra and Richard J. Hargreaves.
Function and regulation of large conductance Ca2 -activated K channel in vascular smooth muscle cells.
Xiang-Qun Hu and Lubo Zhang.
Gene to screen.
Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis.
Luciano Adorini, Mark Pruzanski and David Shapiro.
Non-viral gene therapy for spinal cord regeneration.
Li Yao, Sheng Yao, William Daly, William Hendry, Anthony Windebank and Abhay Pandit.
The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development.
Harriet A. Watkins, Maggie Au and Debbie L. Hay.
Post screen.
The virtuous technology cycle concept and its application in next-generation sequencing.
Ying Pluess-Li, Sandrine Bongiovanni, Edward J. Oakeley, Keith J. Johnson and Frank Staedtler.
Carbon nanotube exploration in cancer cell lines.
Prashant Kesharwani, Raksha Ghanghoria and Narendra K. Jain.
Glucocorticoid-resistant asthma and novel anti-infl ammatory drugs.
Christine R. Keenan, Saad Salem, Ebony R. Fietz, Rosa C. Gualano and Alastair G. Stewart.
Viral targets of acylguanidines.
Elena V. Gazina and Steven Petrou.
Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy.
Priyambada Parhi, Chandana Mohanty and Sanjeeb Kumar Sahoo.