Drug Discovery Today 2012 v.17 №13-14

London, UK.: Elsevier. — 164 p.Since its launch in 1996, Drug Discovery Today has been at the cutting edge of the science underpinning drug discovery and development. Drug Discovery Today delivers highly current reviews to the readers, not only addressing the rapid scientific developments in drug discovery associated technologies, but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed.Contents:
Foundation.
Current therapies in ischemic stroke. Part B. Future candidates in stroke therapy and experimental studies.
Erasmia Broussalis, Eugen Trinka, Monika Killer, Andrea Harrer, Mark McCoy and Jörg Kraus.
Keynote.
Towards a gold standard: regarding quality in public domain chemistry databases and approaches to improving the situation.
Antony J. Williams, Sean Ekins and Valery Tkachenko.
Gene to screen.
Myostatin: more than just a regulator of muscle mass.
Josep M. Argilés, Marcel Orpí, Sílvia Busquets and Francisco J. López-Soriano.
Clinical value of circulating endothelial cell detection in oncology.
Jaco Kraan, Stefan Sleijfer, John A. Foekens and Jan W. Gratama.
Informatics.
Expanding the medicinally relevant chemical space with compound libraries.
Fabian López-Vallejo, Marc A. Giulianotti, Richard A. Houghten and José L. Medina-Franco.
Post screen.
Pathological changes in tight junctions and potential applications into therapies.
Azusa Takahashi, Masuo Kondoh, Hidehiko Suzuki, Akihiro Watari and Kiyohito Yagi.
Case study: technology initiative led to advanced lead optimization screening processes at Bristol-Myers Squibb, 2004–2009.
Litao Zhang, Mary Ellen Cvijic, Jonathan Lippy, James Myslik, Stephen L. Brenner, Alastair Binnie and John G. Houston.
Impact of 5-HT3 receptor antagonists on peripheral and central diseases.
Gohar Fakhfouri, Reza Rahimian, Jean-Eric Ghia, Waliul I. Khan and Ahmad R. Dehpour.
Therapeutic stratagems for vascular degenerative disorders of the posterior eye.
Gaurav K. Jain, Musarrat H. Warsi, Jayabalan Nirmal, Vaidehi Garg, Shadab A. Pathan, Farhan J. Ahmad and Roop K. Khar.
Tuberculosis: from molecular pathogenesis to effective drug carrier design.
Devyani Dube, Govind P. Agrawal and Suresh P. Vyas.
Ribosome-inactivating proteins: current status and biomedical applications.
Munish Puri, Inderdeep Kaur, Matthew A. Perugini and Raghbir C. Gupta.
An overview of natural polymers for oral insulin delivery.
T.A. Sonia and Chandra P. Sharma.
Targeting endothelin receptors for pharmacotherapy of ischemic stroke: current scenario and future perspectives.
Ravinder K. Kaundal, Tushar A. Deshpande, Anil Gulati and Shyam S. Sharma.