Batra Surinder K., Ponnusamy Moorthy P. (eds.) Gene Regulation and Therapeutics for Cancer

CRC Press, 2021. — 328 p. — ISBN: 9781138712423.Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies for different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.Programmed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer.
Nuclear Factor Kappa-B: Bridging Inflammation and Cancer.
The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma.
Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting In Cancer.
Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection.
Targeting Subgroup-Specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma.
Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas.
Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers.
Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications.
Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy.
Therapeutic Options for Prostate Cancer: A Contemporary Update.
Regulation and Targeting of MUCINS in Pancreatic Cancer.
Targeted Therapy for Cancer Stem Cells.