Emadi Ashkan, Karp Judith E. (eds.) Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs

Demos Medical Publishing, 2020. — 301 p. — ISBN: 978-0-8261-6203-8.Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information about each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy to- digest format and replete with detailed images, clinical pearls, and end-of-chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy. Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way, illustrates key concepts for ease of retention, and poses tough questions so readers can problem-solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its-kind manual is a “must-have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees.Anticancer Drug Development: An Introduction.
Alkylating Agents.
Antimetabolites: Hydroxyurea, Pyrimidine and Purine Analogs, and L-Asparaginase.
Antimetabolites: Antifolates.
Antimitotics.
DNA Repair, Apoptotic Pathways, CDK Inhibitors.
Epigenetic Modulators.
Differentiating Agents and Microenvironment.
Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer.
Male Hormonal Therapies.
Targeted Therapies (Small Molecules).
Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents.
Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors.
Multiple Myeloma as a Paradigm for Multi-Targeted Intervention.
Transplant-Related Agents.
Basic Drug Development With Structural Considerations.
Integral Components in Development of Clinical Trials: PK/PD, Statistics, and Principles of Rational Combinatorial Therapies.
Drug Approval and Regulatory Issues.