Dalmau Josep, Graus Francesc. Autoimmune Encephalitis and Related Disorders of the Nervous System

Cambridge University Press, 2022. — 676 p. — ISBN: 978-1-316-51424-5.Autoimmune encephalitis, a disease where the immune system attacks the brain, has become a fast-moving field of study in recent years. The authors, Drs Josep Dalmau and Francesc Graus have played pivotal roles in the discovery of these diseases. Here, they provide a comprehensive clinical guide to the differential diagnosis of these disorders, illustrated with over 200 figures, 30 videos, and numerous clinical vignettes, many from their practice. Clinical descriptions are straightforward, emphasizing distinctive diagnostic clues for each disease. The strengths and weaknesses of diagnostic tests and clinical criteria are discussed extensively, as well as the best evidence supporting the use of available treatments. There is an up-to-date description of immunological triggers and comorbidities and well-illustrated and summarized pathogenic mechanisms and disease models.OverviewImportance, Definitions, History, Classification, and Frequency of the Autoimmune Encephalitides.
General Approach to Diagnosis.
Pathogenesis and Disease Mechanisms in Neuronal Antibody-Mediated Encephalitis.
Antibodies and Antigens
Antibodies to Intracellular Antigens in CNS Disorders.
Antibodies to Neural Cell Surface Antigens.
Specific Syndromes and Diseases
Limbic Encephalitis.
Autoimmunity Against Proteins Associated with Voltage-Gated Potassium Channels.
Anti-NMDAR Encephalitis.
Seizures and Antibodies Against Surface Antigens.
Acute Disseminated Encephalomyelitis and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Neuromyelitis Optica Spectrum Disorders and Glial Fibrillary Acidic Protein Autoimmunity.
Autoimmune Cerebellar Ataxias.
Autoimmune Brainstem Encephalitis.
Autoimmunity Against the Inhibitory Synapsis.
Anti-IgLON5 Disease.
Autoimmune and Inflammatory Encephalopathies as Complications of Cancer.
Deconstructing Hashimoto Encephalopathy.
CNS Syndromes at the Frontier of Autoimmune Encephalitis.
Autoimmunity in Neurological and Psychiatric Diseases
Autoimmune Psychosis.
Psychiatric Manifestations of Autoimmune Encephalitis.
Abnormal Movements in Neurological Autoimmune Disorders.
Sleep and Autoimmunity.
Immunity, Inflammation, and Epilepsy.
Autoimmune Dementia: A Useful Term?
Frequently Asked Questions on Autoimmune Encephalitis and Related Disorders.