Banich M.T., Haber S.N., Robbins T.W. (eds.) The Frontal Cortex: Organization, Networks, and Function

The MIT Press, 2024. — 493 p.An in-depth investigation of the structure, neuronal mechanisms, and computations of the frontal lobe that enable higher-level thought.
Experts from neurobiology, neuroanatomy, evolutionary biology, cognitive neuroscience, computational neuroscience, and clinical science examine how the neuronal structure of the frontal lobes enables unique aspects of higher-level thought. Implications for understanding disrupted function in neurological and psychiatric disorders, as well as societal issues, such as volitional control of behavior and educational practice, are also considered.Framework for Discussion.
Moving Forward.
A Cross-Species Analysis of Prefrontal Cortex Homology Based on Anatomical Connectivity, Behavior, and Cell Types.
Abstract.Comparative Connectivity.
Optogenetic and Chemogenetic Manipulations In Rodents and Primates.
Foraging Innovations, Prediction, and Primate Specialization of PFC.
Cell Types in PFC.
Laminar and Functional Patterns Among Cell Types.
Stability and “Combinatorial Complexity” in PFC.The Two Prefrontal Streams.
Abstract.The Prelimbic Cortex As a Precursor of the Dorsomedial and Dorsolateral Prefrontal Cortex.
Homology between Infralimbic Cortex and vmPFC.Evolutionary Perspectives.
Abstract.What Are the Major Regions and Circuits Observed across Species within the PFC?
How Did the PFC Evolve and How Has This Evolution Led to Produce Higher-Order Cognition, Including Social Behavior and Language Elements in Humans?
What Are the Main Organizational Principles of PFC?
Mechanisms By Which Major Circuits Exert Control: Is There Anything Special about Neuronal Physiology of PFC?
What Unique Contributions Does Work with Optogenetics, chemogenetics, Large-Scale Electrophysiology, and Calcium Imaging Contrib to Understanding PFC Function?
Utility of Animal Models.Neurophysiology.
Abstract.Functional Localization from the View of Neuropsychology.
Contrasting Neuron Responses in OFC and dlPFC.
Reconciling Neuropsychology with Neurophysiology.
Anatomical Organization of Prefrontal Circuitry.
Evolutionary Origins and Ventrodorsal Trends.
Population Coding and Dynamics.
Summary and Open Questions.
The Position of the Prefrontal Cortex in the Cortical Hierarchy.
Abstract.Prefrontal Specializations.
Prefrontal Intrinsic Organization.
Conclusions and Future Directions.What Is the Nature of the Hierarchical Organization of Lateral Prefrontal Cortex?
Abstract.Functional Hierarchy in Rostro-Caudal Lateral PFC.
Hierarchical Interactions Within the RostroCaudal Organization of PFC.
Conclusions and Future Directions.Functional Fractionation and Integration.
Abstract.
General Introduction.
Anatomical Subdivisions in the Frontal Cortex.
If There Is Functional Fractionation of the Frontal Lobes, What Would It Look Like?
Evidence for Functional Fractionation of the Frontal Lobe in Primates.
What Are the Organizational Principles of the Frontal Lobe?
How Do the Frontal Lobes Influence Behavior?
What Are the Key Knowledge Gaps?
How the Brain Creates Unity and Diversity of Executive Functions.
Abstract.Unity and Diversity of Executive Functions.
The Multiple Demand System: Anatomy and Function.
Common EF Versus Spearman’s g.
Conclusions and Future Directions: Beyond Classical Functional Localization.
Computational Models of Prefrontal Cortex.
Abstract.Neural Network Models of PFC Operations.
Computational Cognitive Models of PFC Function.
Concluding Remarks.What Do Network Approaches Add to Our Understanding of Prefrontal Cortex and Executive Function?
Abstract.What Do Network Approaches Add to Our Understanding of the Frontal Lobe?
Challenges and New Frontiers for LargeScale Networks of the Frontal Lobe.Appendix 11.1: Measuring Large-Scale Brain Networks with Resting-State fMRI.
Integrative Psychological, Computational, and Mechanistic Approaches to Frontal Lobe Function.
Abstract.
What Adaptive Functions Does Prefrontal Cortex Serve?
Existing Approaches to Divide the Space of PFC Function.
What Are the Unifying Features of PFC Function?
Computational Modeling in Interplay with Experimentation.
Experimental Approaches: Limitations, Opportunities, and Future Directions.
Conclusions and Open Questions.
Pharmacological Modulation of Prefrontal Cortex in Affective Disorders.
Abstract.Prefrontal Dysregulation in Depression.
Neurochemical Targets for Antidepressants.
Neurochemical Signatures of Prefrontal and Anterior Cingulate Cortices.
Monoamine-Targeting Anxiolytics and Antidepressants.
The Rapidly Acting Antidepressant, Ketamine.
Mu Opioid Receptor Signaling As a Therapeutic Target.
Psychedelic Compounds.
Current Limitations and Future Strategies.
Cognitive Interventions Targeting Executive Functions.
Abstract.
The Malleability of Executive Functions.
Neural Correlates of Executive Function Training: Getting at Underlying Mechanisms.
Executive Function Training in Populations With EF Deficits.
Conclusions, Outstanding Questions, and Implications.
Neurosurgery for Intractable Obsessive-Compulsive Disorder.
Abstract.Frontostriatal Loops and the Psychopathology of OCD.
How Has Invasive Neurosurgery for OCD Contributed to Our Understanding of the PFC?
Cingulotomy.
Anterior Capsulotomy.
Translating Prefrontal Cortex Insights to the Clinic and Society.
Abstract.
The Challenge of Disorders of the Prefrontal Cortex.
Mapping Syndromes and Symptoms to Processes and Etiology.
Comorbidity.
Gradients across Prefrontal Cortex in Health and Disease.
Animal Models Related to Human Disorders.
Improved Targeting of Treatments, with Combinations and Prediction.
Prefrontal Cortex and Society.Pathways Forward Toward an Understanding of Frontal Lobe Function.
Animal Models: Utility, Limitations, and Future Potential.
How Does Connectivity of Frontal Regions Enable Its Functions?
Social Processing, Higher-Order Cognitive Skills, and Development.
Summarizing Statement.