Alkhouri N., Harrison S.A. (eds.) Need-to-Know NAFLD: The Complete Guide to Nonalcoholic Fatty Liver Disease

CRC Press, 2024. — 259 p. — ISBN: 9781032479491.Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease.Mechanisms of NAFLD Development
Historical Perspectives and Clinical Presentation.
Epidemiology and Natural History of Non-Alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis.
Genetics of NAFLD.
Mechanisms of hepatocyte injury and inflammation in NAFLD.
The role of the microbiome.
Diagnostic Tests
Simple Algorithms in Primary Care.
Ultrasound-based techniques in NAFLD.
MRI-based technologies.
Artificial intelligence in NAFLD diagnosis.
Management
Dietary interventions.
Weight Loss Medications.
De novo lipogenesis inhibitors.
Targeting bile acids (FXRs and FGF19).
PPAR agonists.
Anti-inflammatory drugs: Metabolic inflammation in NASH as a therapeutic target.
Practical Aspects of Pharmacologic Management.
Extrahepatic Manifestations
Endocrinology: Diabetes and other endocrinopathies.
Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease.
Extrahepatic Gastrointestinal Manifestations of Non-alcoholic Fatty Liver Disease.
Extrahepatic and Hepatic cancers.
NAFLD in special populations
NAFLD in Children: Unique Aspects and Controversies.
NAFLD in HIV patients.
NAFLD in Liver Transplant Recipients.
NAFLD in lean individuals.