Kaltashov I.A., Eyles S.J. Mass spectrometry in biophysics: Conformation and dynamics of biomolecules

Wiley, 2005. - 481 p. - The book offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future. This is a systematic summary of biophysical mass spectrometry techniques. Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS.
Subsequent chapters address:
Modern spectrometric hardware
High-order structure and dynamics as probed by various MS-based methods
Techniques used to study structure and behavior of non-native protein states that become populated under denaturing conditions
Kinetic aspects of protein folding and enzyme catalysis
MS-based methods used to extract quantitative information on protein-ligand interactions
Relation of MS-based techniques to other experimental tools
Biomolecular properties in the gas phaseGeneral Overview of Basic Concepts in Molecular Biophysics
Overview of Traditional' Experimental Arsenal to Study Biomolecular Structure and Dynamics
Overview of Biological Mass Spectrometry
Mass Spectrometry-Based Approaches to Study Biomolecular Higher-Order Structure
Mass Spectrometry-based Approaches to Study Biomolecular Dynamics: Equilibrium Intermediates
Kinetic Studies by Mass Spectrometry
Protein Interaction: A Closer Look at the "Structure-Dynamics-Function Triad
Synergism Between Biophysical Techniques
Other Biopolymers and Synthetic Polymers of Biological Interest
Biomolecular Ions in a Solvent-Free Environment
Mass Spectrometry on the March: Where Next? From Molecular Biophysics to Structural Biology, Perspectives and Challenges
Appendix: Physics of Electrospray