Mehta Kapil, Siddik Zahid H. (eds.) Drug Resistance in Cancer Cells

Springer, 2009. — 372 p. — ISBN: 978-0-387-89444-7An estimated 1.5 million patients in the United States are diagnosed with cancer every year and over half-a-million individuals die of the disease. Since the vast majority of the deaths occur after medical intervention with anticancer therapy, both conventional chemotherapy and novel targeted therapy, it can be concluded that these patients die from drug resistant cancers. A growing number of studies have revealed that mechanisms underlying the development of drug resistance in cancer cells are manifold and complex and very likely are dependent on cell and microenvironment context. In view of these facts, it is important to document the mechanisms of drug resistance and understand which are the dominant resistance pathways in a particular tumor type that could provide potential therapeutic targets in a clinical setting.This book serves as a single source for the current knowledge on genetic and epigenetic alterations that contribute to the development of drug resistance. Comprehensive reviews written by renowned experts provide great insight on the current knowledge on drug resistance mechanisms. This book is a ready source of information to clinicians, cell and cancer biologists and defines molecular drug resistance mechanisms that are challenging scientists and clinical oncologists today.Multidrug Resistance Mediated by MDR-ABC Transporters
Metastasis and Drug Resistance
The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer
Mechanisms of Resistance to Targeted Tyrosine Kinase Inhibitors
Targeting Transglutaminase-2 to Overcome Chemoresistance in Cancer Cells
Extracellular Matrix-Mediated Drug Resistance
Oxidative Stress and Drug Resistance in Cancer
Nuclear Factor-κB and Chemoresistance: How Intertwined Are They?
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
Resistance to Differentiation Therapy
MicroRNAs and Drug Resistance
Molecular Signatures of Drug Resistance
Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging
Overcoming Drug Resistance by Phytochemicals