Imanaka Tsuneo, Shimozawa Nobuyuki (eds.) Peroxisomes: Biogenesis, Function, and Role in Human Disease

Springer, 2019. — 284 p. — ISBN: 978-981-15-1168-4This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.Biogenesis and Function of Peroxisome
The History of Peroxisomal Research
Peroxisome Biogenesis
Peroxisome Degradation and Its Molecular Machinery
The Function of the Peroxisome
Dysfunction of Peroxisome and Human Disease
Peroxisomal Disorders
Model Organisms for Understanding Peroxisomal Disorders
Diagnosis of Peroxisomal Disorders
Therapeutic Strategies for X-Linked Adrenoleukodystrophy, a Representative Peroxisomal Disorder
Topics in Peroxisome Research
The Isolation of Peroxisomes
Structure Biology of Peroxisomal Proteins, Peroxins
Lipidomics of Peroxisomal Disorders
Neurophysiology and Neuropsychology in Adrenoleukodystrophy (ALD)