Crocker J., Murray P.G. (eds.) Molecular Biology in Cellular Pathology

Wiley, 2003. - 394 p. - Molecular biology has had a major impact on the practice of pathology in recent years and this continues with the new approaches being developed in genomics and proteomics. Knowledge of the molecular organization of the cell has led to the development of powerful new techniques which bring greater accuracy and objectivity to the diagnosis, prognosis and management of many diseases, and to the study of pathological states. This book is a completely revised and updated version of the popular Molecular Biology in Histopathology, with added material covering the latest methodologies and now featuring colour plates. It describes the molecular techniques available and provides an overview of how they can be applied. It is aimed at histopathologists in training, clinicians and biologists studying for post-graduate qualifications and will also be of interest to biochemists, physiologists, pharmacologists and biotechnologists, in academia, clinical medicine and industry.Preface to Molecular Biology in HistopathologyBlotting Techniques: Methodology and Applications
In-situ Hybridisation in Histopathology
DNA Flow Cytometry
Interphase Cytogenetics
Oncogenes
Molecular and Immunological Aspects of Cell Proliferation
Interphase Nucleolar Organiser Regions in Tumour Pathology
Apoptosis and Cell Senescence
The Polymerase Chain Reaction
Laser Capture Microdissection: Technique and Applications in the Molecular Analysis of the Cancer Cell
The In-situ Polymerase Chain Reaction
TaqMan Technology and Real-Time Polymerase Chain Reaction
Gene Expression Analysis Using Microarrays
Comparative Genomic Hybridisation in Pathology
DNA Sequencing and the Human Genome Project
Monoclonal Antibodies: The Generation and Application of 'Tools of the Trade' Within Biomedical Science
Proteomics