Tan S.-L. (Ed.) Immuno-Oncology: Cellular and Translational Approaches

Springer, 2020. — 267 p. — (Methods in Pharmacology and Toxicology). — ISBN: 978-1-0716-0170-9.This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab.
Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics.An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies
High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry
In Vitro Functional Assay Using Real-Time Cell Analysis for Assessing Cancer Immunotherapeutic Agents
Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays
Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates
A Human In Vitro T Cell Exhaustion Model for Assessing Immuno-Oncology Therapies
Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay
3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment
Considerations in Developing Reporter Gene Bioassays for Biologics
Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies
Precision Medicine: The Function of Receptor Occupancy in Drug Development
In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics
The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era