Van Regenmortel Marc H.V. (ed.) HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design: A Review of 20 Years of Research

Springer, 2019. — 379 p. — ISBN: 978-3-030-32458-2This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.Immunochemistry
What Is a B Cell Epitope
Molecular Design Versus Empirical Discovery in Peptide-Based Vaccines: Coming to Terms with Fuzzy Recognition Sites and Ill-Defined Structure-Function Relationships in Immunology
Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes
Specificity, Polyspecificity and Heterospecificity of Antibody-Antigen Recognition
Reductionism
Reductionism and the Search for Structure: Function Relationships in Antibody Molecules
Reductionism and Complexity in Molecular Biology: Scientists Now Have the Tools to Unravel Biological Complexity and Overcome the Limitations of Reductionism
Editorial: Biological Complexity Emerges from the Ashes of Genetic Reductionism
The Rational Design of Biological Complexity: A Deceptive Metaphor
Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking
Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking
Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases
The Search for a Preventive HIV Vaccine
Limitations to the Structure-Based Design of HIV-1 Vaccine Immunogens
Two Meanings of Reverse Vaccinology and the Empirical Nature of Vaccine Science
Requirements for Empirical Immunogenicity Trials, Rather than Structure-Based Design, for Developing an Effective HIV Vaccine
Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013
Editorial: Paradigm Changes Are Required in HIV Vaccine Research
An Outdated Notion of Antibody Specificity Is One of the Major Detrimental Assumptions of the Structure-Based Reverse Vaccinology Paradigm, Which Prevented It from Helping to Develop an Effective HIV-1 Vaccine
More Surprises in the Development of an HIV Vaccine (General Commentary)
Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 Not Inform the Rational Design of an HIV-1 Vaccine?
Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop Held in Rome on 17 June 2016
Structure-Based Reverse Vaccinology Failed in the Case of HIV Because It Disregarded Accepted Immunological Theory
Immune Systems Rather than Antigenic Epitopes Elicit and Produce Protective Antibodies Against HIV
Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design
Viral Species, Viral Genomes and HIV Vaccine Design: Is the Rational Design of Biological Complexity a Utopia?