Heuser R.R., Schlaich M.P., Sievert H. (eds.) Renal Denervation: A New Approach to Treatment of Resistant Hypertension

Springer, 2015. — 203 p. — ISBN: 978-1-4471-5222-4Hypertension remains the leading cause of cardiovascular morbidity and mortality in spite of current medical therapies. It has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension. Renal denervation (RDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension. Early studies show a high degree of effectiveness in renal denervation to treat hypertension.This book examines renal pathophysiology and the rationale for renal denervation, as well as possible long term benefits and risks of this new therapy. The myriad of devices involved in the evolution of this therapy are discussed and the book concludes with analyses of the cost effectiveness and future applications.Pathophysiology: The Target for Renal Denervation
Physiological Rationale for Renal Denervation Therapy in Hypertension
Preclinical Model and Histopathology Translational Medicine and Renal Denervation
The Endpoint on Measuring the Clinical Effects of Renal Denervation: What Are the Best Surrogates
Appraisal of the Clinical Trial Data on Renal Denervation for the Management of Resistant Hypertension
Catheter-Based Technology Alternatives for Renal Denervation: An Overview
Medtronic Ardian Symplicity Renal Denervation Devices
Sympathetic Renal Denervation Using the EnligHTN Multi-electrode Ablation System: The St Jude Experience
ReCor Medical Paradise Renal Denervation System
Therapeutic Intra Vascular Ultrasound (TIVUS)
The “OneShot” Irrigated Balloon-Mounted Spiral Electrode Renal Denervation Device
NOVOSTE: The Brachytherapy Approach to Renal Denervation
Perivascular Renal Denervation (PVRDTM): Chemical Renal Denervation with Micro-Doses of Ethanol Using the PeregrineTM Renal Denervation Device
Vincristine Local Delivery for Renal Artery Denervation
NephroBlate Renal Denervation System: Urologic-Nephrologic Based Approach to Resistant Hypertension
Targeted Renal Nerve Deactivation by Neurotropic Agents
Boston Scientific Vessix Renal Denervation System
Radiofrequency and Irrigated Ablation: Principles and Potential for Renal Artery Denervation (RDN) in the Treatment of Resistant Arterial Hypertension
Renal Denervation: Potential Future Implications Beyond Resistant Hypertension
Renal Denervation for Congestive Heart Failure
Great Myths of Blood Pressure Effect Size in Renal Denervation
The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease
Diabetes and Metabolic Syndrome
Obstructive Sleep Apnea