Pritchard-Jones Kathy, Dome Jeffrey S. (eds.) Renal Tumors of Childhood: Biology and Therapy

Springer, 2014. — 286 p. — (Pediatric Oncology) — ISBN: 978-3-662-44002-5This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practicing clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.Epidemiology of Renal Tumours of Childhood
Genetic Predisposition to Wilms Tumour
Clinical Presentation
Pathology of Renal Tumours of Childhood
Treatment of Wilms Tumor in the Children’s Oncology Group
Treatment of Wilms Tumour: The SIOP Approach
Treatment of Relapsed Wilms Tumor
Imaging
Biological Prognostic Factors in Wilms Tumors
Molecular-Targeted Therapy for Pediatric Renal Tumors
Surgical Consideration for Wilms’ Tumors and Other Neoplastic Renal Lesions
Radiotherapy for Wilms’ Tumour and Other Childhood Renal Cancers
Late Effects and QOL Chapter
Non-Wilms Pediatric Renal Tumors
Wilms Tumour in Countries with Limited Resources