Carrell Douglas T. (ed.) Paternal Influences on Human Reproductive Success

Cambridge University Press, 2013. — 221 p. — ISBN: 978-1-107-02448-9Historically, sperm have been seen as simply a mechanism of transferring a haploid set of chromosomes to the oocyte. However, data from assisted reproduction therapies (ART) have demonstrated that in many couples the sperm appears to be responsible for abnormal embryogenesis. Recent advances in genetic and epigenetic techniques have identified key mechanisms by which the sperm, and the DNA carried by the sperm, can affect early embryonic development. Paternal Influences on Human Reproductive Success examines the genetic and epigenetic influences on embryogenesis, as well as practical clinical factors related to the male contribution to reproductive success. It also provides 'cutting edge' data and analysis of recent evaluations of the role of advanced paternal age, environmental influences and lifestyle factors on male reproductive fitness, making this an invaluable text for physicians treating patients for infertility, recurrent pregnancy loss, and developmental anomalies, as well as basic scientists studying embryogenesis and spermatogenesis.Advances in Understanding the Male Gamete
The reproductive fitness of the human male gamete
The sperm genome: effect of aneuploidies, structural variations, single nucleotide changes and DNA damage on embryogenesis and development
The sperm epigenome: a role in embryogenesis and fetal health?
Imprinted gene anomalies in sperm
Has the renewed interest in sperm RNA led to fresh insights? A critical review and hypothesis
The role of the sperm centrosome in reproductive fitness
The Influence of Aging and Environmental Factors on Male Reproductive Fitness
The male biological clock
The role of aging on fecundity in the male
Aging, DNA damage, and reproductive outcome
Paternal aging and increased risk of congenital disease, psychiatric disorders, and cancer
Sexual function in the aging male
Supplements and replacement therapies for the aging male and their effects on reproductive fitness
Environment and lifestyle effects on fertility
Obesity and male infertility: is there an effect on embryogenesis?
Clinical Laboratory Concepts and Considerations
ICSI: does the sperm matter?
Sperm selection and ART outcome: a means to overcome the effects of aging and abnormal spermatogenesis?
Variability of human semen quality: caution in interpreting semen analysis data
Semen characteristics and aging: technical considerations regarding variability