6th edition. — ASM Press, 2011. — 656 p. — ISBN: 9781555815134
One-third of the world’s human population is currently infected with tuberculosis. Tuberculosis remains epidemic, causing close to two million deaths each year. Most of these deaths occur in developing nations; however, developed nations also struggle with tuberculosis, contending with such growing challenges as drug resistance, immigration, immunosuppression, and nontuberculous mycobacterial infection. Nearly 30 years after the publication of the first edition, the Sixth Edition of this comprehensive reference gathers the most current science and tools available in the fight against tuberculosis, enabling readers to fully understand the underlying mechanisms of tuberculosis and correctly diagnose and manage the disease.Tuberculosis and Nontuberculous Mycobacterial Infections is divided into three sections. Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. Section II covers both classic and more recent clinical manifestations of tuberculosis infection. Separate chapters address every organ system as well as issues unique to pregnancy, infants and children, HIV infection, organ transplantation and immune reconstitution inflammatory syndrome. Section III explores nontuberculous mycobacterial infections, including a detailed discussion of the clinical syndromes produced by these organisms.All the chapters have been written by leading experts whose experience ranges from basic and clinical research to bedside medicine.
General ConsiderationsTuberculosis in History: Did It Change the Way We Live?
Epidemiology and Host Factors
Pathophysiology and Immunology
Laboratory Diagnosis and Susceptibility Testing
Diagnosis of Latent Tuberculosis Infection
Treatment of Latent Tuberculosis Infection
Chemotherapy of Tuberculosis
Therapy of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Role of Surgery in the Diagnosis and Management of Tuberculosis
Mycobacterium bovis BCG and New Vaccines against Tuberculosis
Tuberculosis — a World Health Organization Perspective
Tuberculosis in Enclosed Populations
Role of the Health Department — Legal and Public Health Considerations
Clinical SyndromesPulmonary Tuberculosis
Upper Respiratory Tract Tuberculosis
Tuberculous Otomastoiditis
Ocular Tuberculosis
Central Nervous System Tuberculosis
Tuberculous Lymphadenitis and Parotitis
Urogenital Tuberculosis
Musculoskeletal Tuberculosis
Cardiovascular Tuberculosis
Gastrointestinal Tuberculosis
Tuberculous Peritonitis
Tuberculosis of the Liver, Biliary Tract, and Pancreas
Cutaneous Tuberculosis
Miliary Tuberculosis
Endocrine and Metabolic Aspects of Tuberculosis
Hematologic Complications of Tuberculosis
Tuberculosis in Infants and Children
Pregnancy: Maternal, Fetal, and Neonatal Considerations
Tuberculosis Associated with HIV Infection
Tuberculosis and Organ Transplantation
Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome
Nontuberculous MycobacteriaNontuberculous Mycobacteria — Introduction
Mycobacterium avium Complex Disease
Rapidly Growing Mycobacteria
Mycobacterium kansasii
Mycobacterium marinum
Mycobacterium scrofulaceum
Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex
Other Nontuberculous Mycobacteria