Kumar S., Chukwuebuka E. (Eds.) Phytochemistry: An in-silico and in-vitro Update: Advances in Phytochemical Research

Springer, 2019. — 574 p. — ISBN: 978-981-13-6919-3.Phytochemistry is the branch of science that deals with the study of plant-derived chemicals or compounds, which are also known as phytochemicals or plant-derived secondary metabolites. Plants are known to produce phytochemicals that are essential for their growth and reproduction, as they protect them from insects, pathogens, and herbivores. Some of the major groups of plant-derived secondary metabolites are phenolics, flavonoids, terpenoids, alkaloids, tannin etc.
Plant-derived phytochemicals are pharmacologically active and have the potential to cure various human diseases and disorders. Natural plant products have been known for their medicinal properties for untold years, and form the basis of several medicinal systems such as Chinese, Unani, and Ayurvedic Medicine.
This book offers an essential introduction to phytochemicals and their synthetic analogues. It discusses various in silico approaches used to identify pharmacologically active phytochemicals and their biological activities, as well as in vitro and in vivo models/assays that have been utilized for the pharmacological profiling of plant-derived products to combat cancer, diabetes, cardiovascular diseases and neurological disorders.
The intended audience includes upper-level undergraduate and graduate students; researchers and scientists from the pharmaceutical/food chemistry/nutrition sciences/biochemistry, and clinical biochemistry fields; and medical students. Sharing the latest findings, the book will familiarize these readers with the concepts, chemistry, and tremendous potential of phytochemistry.Phytochemicals as Sources of Drugs
Synthetic Analogs of Phytochemicals
Phytochemicals as Anticancer Drugs: Targeting the Microtubular Network of Cancer Cells
Reprogramming of Tumor Associated Immune Cells by Phytochemicals: In-vitro Approaches for Cancer Treatment
Recent Advances in Phytochemicals and Their Synergistic Role in Multiple Myeloma
Drug Resistance in Plasmodium sp. and Novel Antimalarial Natural Products-Emerging Trends
Bacterial Cell Division Machinery: An Insight for Development of New Antibacterial Agent
Immunomodulatory Potential of Phytochemicals: Recent Updates
Health Benefits and Pharmacological Molecular Properties of Isoflavandiol (Equol): In-silico and in-vitro Updates
Anticancer and Neuroprotective Activity of Chrysin: Recent Advancement
Screening of Natural Antidiabetic Agents
In-vitro Models to Assess Antioxidant Potential
In-vitro Models in Anticancer Screening
In-vitro Techniques to Study Cell Signaling
In-vitro Assays for Antimicrobial Assessment
In-vitro Assays for Determining Anti-HIV Potential of Phytochemicals
Nanoencapsulation of Phytochemicals and in-vitro Applications
Phytotherapy in Inflammatory Lung Diseases: An Emerging Therapeutic Interventional Approach
In-silico Tools in Phytochemical Research
In-silico Approach to Target Cancer Cell DNA Repair Pathway
In-silico Targets in Immune Response
In-silico Targets in Neurodegenerative Disorders
Phytochemicals, Cancer and miRNAs: An in-silico Approach
Protein Homology Modeling in Phytochemical Research
In-silico Approaches to Study Therapeutic Efficacy of Nutraceuticals
Bulbine frutescens Phytochemicals as a Promising Anti-cancer Drug Discovery Source: A Computational Study
PtRFdb: Plant tRNA-Derived Fragments Database
In-silico Methods of Drug Design: Molecular Simulations and Free Energy Calculations
Study of Plant Exclusive Virus-Derived Small Interfering RNAs
Association Between Nuclear Receptor Coactivator 1 and Stem Cell Signaling Pathway and Identification of Natural NCOA1 Inhibitors: An in-silico Study
Parthenin and Its Similar Structure as Potential Lead Inhibitors of Plasmodium vivax and Plasmodium falciparum Lactate Dehydrogenase