Fischer J., Christian Klein C., Childers W.E. (ed.) Successful Drug Discovery. Volume 3

Wiley‐VCH Verlag GmbH & Co., 2018. 467 p.The third volume of Successful Drug Discovery has a structural similarity to the first volume consisting of three parts: General Aspects, Drug Class Studies, and Case Histories. The book series supported by the International Union of Pure and Applied Chemistry (IUPAC) focuses on new drug discoveries.This volume investigates drug discoveries of the last years, that is, small-molecule drugs and biologics approved between 2013 and 2016. The book therefore contains both medicinal chemistry and biological drug research with a concept to bring these two disciplines closer to each other.General Aspects.
New Trends in Drug Discovery.
Patenting Small and Large Pharmaceutical Molecules.
Drug Class Studies.
Kinase Inhibitor Drugs.
Evolution of Nonsteroidal Androgen Receptor Antagonists.
Case Studies.
Development of T-Cell-Engaging Bispecific Antibody Blinatumomab (Blincyto) for Treatment of B-Cell Malignancies.
Ceritinib: A Potent ALK Inhibitor for the Treatment of Crizotinib-Resistant Non-Small Cell Lung Cancer Tumors.
Discovery, Development, and Mechanisms of Action of the Human CD38 Antibody Daratumumab.
The Discovery of Obeticholic Acid (OcalivaTM): First-in-Class FXR Agonist.
Discovery and Development of Obinutuzumab (GAZYVA, GAZYVARO), a Glycoengineered Type II Anti-CD20 Antibody for the Treatment of Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia.
Omarigliptin (MARIZEVTM, MK-3102).
Opicapone, a Novel Catechol-O-Methyltranferase Inhibitor (COMT) to Manage the Symptoms of Parkinson’s Disease.
The Discovery of Osimertinib (TAGRISSOTM): An Irreversible Inhibitor of Activating and T790M Resistant Forms of the Epidermal Growth Factor Receptor Tyrosine Kinase for the Treatment of Non-Small Cell Lung Cancer.
Discovery of Pitolisant, the First Marketed Histamine H3-Receptor Inverse Agonist/Antagonist for Treating Narcolepsy.
Discovery and Development of Safinamide, a New Drug for the Treatment of Parkinson’s Disease.
Discovery and Development of Trifluridine/Tipiracil (Lonsurf TM).