Shukla A.A., Etzel M.R., Gadam S. (eds.) Process Scale Bioseparations for the Biopharmaceutical Industry

CRC Press, 2007. - 574 p.
The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers.Harvest of a Therapeutic Protein Product from High Cell Density
Fermentation Broths: Principles and Case Study
Expanded Bed Adsorption for Capture from Crude Solution
Product Recovery by High-Gradient Magnetic Fishing
Protein Refolding and Scale Up
Bulk Protein Crystallization — Principles and Methods
Modes of Preparative Chromatography
Screening of Chromatographic Stationary Phases
A Priori Prediction of Chromatographic Separations from Protein Structure Data
Membrane Chromatography: Analysis of Breakthrough Curves and Viral Clearance
Ultrafiltration Process Design and Implementation
Virus Filtration Process Design and Implementation
Product Recovery from Transgenic Sources
Analytical Strategy for Biopharmaceutical Development
Evaluation of Viral Clearance in Purification Processes
Advances in Viral Clearance
Protein A Affinity Chromatography for Capture and Purification of Monoclonal Antibodies and Fc-Fusion Proteins: Practical Considerations for Process Development
Polishing Methods for Monoclonal IgG Purification
Making Changes to a Biopharmaceutical Manufacturing Process during Development and Commercial Manufacturing: The REMICADE Story
Linear Scale-Up of Ultrafiltration of High Viscosity Process Streams
A Membrane Chromatography Application: A Rapid, High Capacity Gene Therapy Vector Purification Tool