Rodrigues A. David (ed.) Drug-Drug Interactions

2nd edition. — Informa Healthcare, 2008. — 770 p. — ISBN: 9780849375934Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Introducing Pharmacokinetic and Pharmacodynamic Concepts
In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes
Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions
UDP-Glucuronosyltransferases
Drug-Drug Interactions Involving the Membrane Transport Process
In Vitro Models for Studying Induction of Cytochrome P450 Enzymes
In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450
The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development
Cytochrome P450 Protein Modeling and Ligand Docking
Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions
Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro–In Vivo Correlations
Transporter-Mediated Drug Interactions: Molecular Mechanisms and Clinical Implications
Metabolism and Transport Drug Interaction Database: A Web-Based Research and Analysis Tool
In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans
Drug-Drug Interactions: Clinical Perspective
An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective
Drug-Drug Interactions: Toxicological Perspectives
Drug-Drug Interactions: Marketing Perspectives