Manson JoAnn E., Buring J.E. et al. (eds.) Clinical Trials in Heart Disease: A Companion to Braunwald's Heart Disease

2nd edition. — Elsevier, 2004. — 444 p. — ISBN: 978-0721604084This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice.This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.Methodology
Contributions of Basic Research, Observational Studies, and Randomized Trials
Methodology of Randomized Trials
Comparative Features of Primordial, Primary and Secondary Prevention Trials
Principles of Data and Safety Monitoring Boards in Randomized Trials
Treatment Trials: Treatment of Acute Coronary Ischemia
Aspirin and Thienopyridines
Heparin and Low Molecular Weight Heparin in Acute Coronary Ischemia
Clinical Trials in Thrombolytic Therapy
Clinical Trials of Direct Thrombin Inhibitors
Glycoprotein IIb/IIIa Receptor Inhibitors
Adjunctive Medical Therapy for Acute Myocardial Infarction
Primary, Rescue and Adjunctive Mechanical Intervention in the Setting of Acute Myocardial Infarction
Coronary Artery Bypass Surgery in Acute Coronary Syndromes
Treatment Trials: Treatment of Arrhythmias
Drug Therapy for Ventricular Tachycardia and Ventricular Fibrillation
Antiarrhythmic Drug Therapy in Supraventricular Tachycardia
Anticoagulant and Antiplatelet Drug Therapy for Atrial Fibrillation
Clinical Trials in Arrhythmia Ablation
Clinical Trials of Implantable Cardioverter-Defibrillators (ICDs) and Cardiac Resynchronization Therapy/Defibrillation
Clinical Trials in Pacing
Treatment Trials: Treatment of Congestive Heart Failure
Drugs Blocking the Renin-Angiotensin-Aldosterone System (RAAS)
Beta-blocker Treatment of Heart Failure
Clinical Trials in Heart Transplantation and Mechanical Cardiac Support for End-Stage Heart Failure
Primary and Secondary Prevention Trials
Cholesterol Reduction
Blood Pressure Reduction Treatment Trials
Prevention Trials of Smoking Cessation
Physical Activity and Weight Loss
Aspirin, Other Antiplatelet Agents, and Anticoagulant Agents in the Secondary and Primary Prevention of Cardiovascular Disease
Postmenopausal Hormone Replacement Therapy
Antioxidant Vitamins
Dietary Factors
Cardiac Psychology/Behavioral Cardiology
Multiple Risk Factor Intervention Trials
Prevention Strategies: From the Office to the Community and Beyond