Scott P.J.H., Hockley B.G. (Eds.) Radiochemical Syntheses. Volume 1: Radiopharmaceuticals for Positron Emission Tomography

Wiley, 2012. — 346 p. — ISBN9780470588956.The ultimate reference guide to the synthesis of radiopharmaceuticals
The Radiochemical Syntheses series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory.
Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self-contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience.
Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.Fluorine‐18 Labeled Radiopharmaceuticals
Synthesis of [18F]‐Fluorodeoxyglucose ([18F]FDG)
Synthesis of Sodium [18F]Fluoride (Na[18F]F)
Radiosynthesis of 3′‐Deoxy‐3′‐[18F]Fluorothymidine ([18F]FLT)
Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA)
Synthesis of [18F]Fluoromisonidazole (1‐(2‐Hydroxy‐3‐[18F]Fluoropropyl)‐2‐Nitroimidazole, [18F]FMISO)
Synthesis of [18F]FPPRGD2
Synthesis of [18F]Fluorocholine ([18F]FCH)
Clinical Manufacturing of [18F]‐16‐α‐Fluoroestradiol ([18F]FES)
Synthesis of N‐Succinimidyl 4‐[18F]Fluorobenzoate ([18F]SFB)
Synthesis of 4‐(2′‐Methoxyphenyl)‐1‐[2′‐(N‐2″Pyridinyl)‐p‐[18F]Fluorobenzamido]Ethylpiperazine [18F]
Synthesis of [18F]‐Fallypride
Synthesis of [18F]Fluoroethyltyrosine (18F‐FET)
Synthesis of [18F]Flumazenil ([18F]FZ)
Synthesis of 6‐[18F]Fluorodopamine (6‐[18F]FDA)
Synthesis of 2‐([18F]Fluoro)‐3‐[(2S)‐2‐Azetidinylmethoxy]Pyridine ([18F]2FA)
Synthesis of [18F]‐Substance‐P Antagonist‐Receptor Quantifier ([18F]SPA‐RQ)
Carbon‐11 Labeled Radiopharmaceuticals
Synthesis of [11C]Choline Chloride ([11C]CHL)
Synthesis of 2‐(4‐N‐[11C]Methylaminophenyl)‐6‐Hydroxybenzothiazole ([11C]6‐OH‐BTA‐1; [11C]PIB)
Synthesis of [11C]‐meta‐Hydroxyephedrine ([11C]MHED)
Synthesis of L‐[methyl‐11C]Methionine ([11C]MET)
Synthesis of (+)‐α‐[11C]Dihydrotetrabenazine ([11C]DTBZ)
Synthesis of [11C]Flumazenil([11C]FMZ)
Synthesis of [11C]Hexadecanoic Acid ([11C]Palmitic Acid)
Synthesis of O‐methyl‐11C]Metomidate ([11C]‐MTO)
Synthesis of [11C]Carfentanil ([11C]CFN)
Synthesis of [carbonyl‐11C]Way‐100635
Synthesis of [11C]Raclopride
Synthesis of 3‐Amino‐4‐[2‐(N‐Methyl‐N‐[11C]Methyl‐Amino‐Methyl)Phenylsulfanyl]‐Benzonitrile ([11C]DASB)
Synthesis of [11C]Acetate
Synthesis of N‐(2‐[11C]Methoxybenzyl)‐N‐(4‐Phenoxypyridin‐3‐yl)Acetamide ([11C]PBR28)
Other Radiopharmaceuticals
Synthesis of [13N]Ammonia ([13N]NH3)
Synthesis of [68Ga]Gallium Dota‐(Tyr3)‐Octreotide Acetate ([68Ga]‐Dotatoc)
Appendix: Supplier Information