Jastrzab R., Tylkowski B. (ed.) New-Generation Bioinorganic Complexes

Walter de Gruyter GmbH, 2016. 188 p. ISBN: 978-3-11-034880-4
Bio-Inorganic compounds are successfully applied as therapeutic agents since decades. Thus, scientist designed new metal complexes bearing biomolecules as ligands, investigating their potential as bioactive and therapeutic agents. This book presents a comprehensive overview on materials design, substance classes and their characterization. This book is compiled for scientists interested in medical application of bioinspired materials.
Chapter 1 describes noncovalent interactions which perform essential roles in biological systems such as molecular recognition, protein stabilization, specificity, and efficiency of enzymatic reactions. Chapter 2 provides an overview on photosensitive complexes based on azobeznene compounds and their applications. Chapters 3 details complexes of biogenic amines in the aspect of their role in living systems, while Chapter 4 emphasizes synthetic aspects, crystal structures, and biological activities of d- and f-metal salen-type complexes, respectively. Knowledge about metal ions’ interaction with proteins, nucleic acids, and other organic moieties is very important for the development of new pharmaceuticals and medicine. The topics detailed in Chapters 5–7 provide current developments and applications of bio-complexes extremely useful in radiochemistry and anticancer therapy.Noncovalent interactions in biocomplexesNoncovalent interactions in metal complexes
Some historical backgrounds
Types of interactions in and around metal complexes
Characterisation of interactions
Interactions within complex molecules
Through-metal ligand‒ligand interactions
Through-space ligand‒ligand and metal‒ligand interactions
Detection and evaluation of ligand‒ligand interactions in solution
Stability constants
Spectral data
Ligand‒ligand interactions in ternary metal complexes involving amino acids
Stability enhancement
Structure and selectivity
Structural and functional characterisation of noncovalent interactions in chemistry and biology
Association of oppositely charged ions in Cu(II)‒arginine complexes
Interactions between metal complexes and surrounding groups
Adduct formation and its effect
Protein‒small molecule interactions
Interactions involving coordinated ligands at the metal site of proteins
Close contact between the metal center and the side chain groups
Metal‒aromatic ring interactions
Interactions involving a hydrogen atom
Concluding remarksPhoto-sensitive complexes based on azobenzene
Azobenzene
UV-sensitive complexes
Azobenzene with nickel (Ni)
Azobenzene with platinum (Pt) and palladium (Pd)
Azobenzene with cobalt (Co)
Azobenzene with manganese (Mn), rhenium (Re) and ruthenium (Ru)
Azobenzene with ferro (Fe) and zinc (Zn)
Azobenzene with Copper (Cu)Complexes of biogenic amines in their role in living systemsPolyamines in living systems
Polyamines as tumour markers
Weak interactions of polyamines
Complex formation of bioamines
Application of polyamine complexes in medicineSynthetic aspects, crystal structures and biological activities of d- and f-metal salen-type complexes
Synthesis and crystal structure of d-metal salen-type complexes
Synthesis and crystal structure of metal salen-type complexes
Synthesis and crystal structure of the heteronuclear salen-type complexes of d- and f-metal ion
Biological activities of d- and f-metal salen-type complexesBiocomplexes in radiochemistryBone-seeking complexes
Diagnostic bone-seeking radiopharmaceuticals
Development of novel diagnostic bone-seeking technetium complexes
Development of novel diagnostic bone-seeking gallium complexes for PET
Bone-seeking radiopharmaceuticals for palliative therapy of bone metastases
Development of novel bone-seeking complexes for palliation therapy of bone metastases
Radio-complexes for imaging of apoptosis
Technetium-labeled annexin A5
99mTc-4, 5-bis(thioacetamido)pentanoyl-annexin A5 (99mTc-BTAP-annexin A5)
99mTc-HYNIC-annexin A5
99mTc-labeled annexin A5 constructed with histidine residues
99mTc-C3(BHam)2-annexin A5
68Ga-labeled annexin A5
Summary of radiolabeled annexin A5 for imaging of apoptosisPeptides and biocomplexes in anticancer therapy
General introduction on cancer
Cancer and metastasis origins and global burden
Genomic instability and the other side of the Darwinian coin
The hallmarks of cancer
Molecular basis of the metastatic cascade
General used therapies of cancer
Therapy against cancer and metastasis
Biocomplexes in cancer therapy
Photodynamic therapy (PDT)
Metal complexes as platforms for cancer therapy
Platinum-based cancer therapy: a start of a new phase
Zinc in cancer therapy
Copper in cancer therapy
Peptide therapeutics
Peptides in cancer therapy
TAT-RasGAP317–326 as a dual sensitizer and anti-metastatic toolDevelopments in platinum anticancer drug
Discovery of anticancer activity of cisplatin
Platinum complexes
Platinum (II) complexes
Platinum (IV) complexes
Anticancer drug delivery