Krautenbacher N. Learning on complex, biased, and big data: disease risk prediction in epidemiological studies and genomic medicine on the example of childhood asthma

Technical University of Munich, 2018. — 186 p.Predicting the risk of complex diseases is a field of growing relevance in medicine and shows high potential of refinement and improvement by integrating new data types and larger data sets. In this thesis, we investigate and overcome issues on several challenges in this field by applying and developing statistical methodology for working with complex data structures and we show how prediction for diseases can be improved by taking into account bias, complexity and bigness of data.