Zimlichman Reuven, Julius Stevo, Mancia Giuseppe (eds.) Prehypertension and Cardiometabolic Syndrome

Springer, 2019. — 674 p. — (Updates in Hypertension and Cardiovascular Protection) — ISBN: 978-3-319-75309-6This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines.While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation.In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.Epidemiology and Statistics
High-Normal Blood Pressure in Children and Adolescents
History of Prehypertension: Past and Present, a Saga of Misunderstanding and Neglect
Parental History of Hypertension as the Determinant of Cardiovascular Function
Prehypertension, the Risk of Hypertension and Events
Prehypertension and the Cardiometabolic Syndrome
Prehypertension: Definition and Epidemiology
Prehypertension, Statistics and Health Burden
Organ Damage in Prehypertension
Arterial Stiffness in Early Phases of Prehypertension
Central Blood Pressure and Prehypertension
Diurnal and Pulsatile Hemodynamics in Individuals with Prehypertension
Early Changes in Renal Vasculature in Prehypertension
Heart and Prehypertension
Hemodynamics of Prehypertension
Microvascular Structural Alterations and Tissue Perfusion in Hypertension/Diabetes
Obesity-Hypertension Physiopathology and Treatment: A Forty-Year Retrospect
Pre-chronic Kidney Disease (CKD)? Is It Time for a New Staging?
Prehypertension and Vascular-Renal Impairment
Subclinical Vascular Damage in Prehypertension
Systolic Hypertension in Youth
The Role of Perivascular Fat in Raising Blood Pressure in Obesity and Diabetes
Alteration of Cardiovascular Control Systems
Endothelial Dysfunction in Early Phases of Hypertension
Prehypertension and the Renin-Angiotensin-Aldosterone System
Tachycardia in Prehypertension
The Role of the Brain in Prehypertension
The Role of the Brain in Neurogenic Prehypertension
Risk Assessment in Prehypertension
Blood Pressure and Atherosclerosis: Subclinical Arteriosclerosis as an Early Sign of Organ Damage
Blood Pressure Measurement, White-Coat and Masked Hypertension
Blood Pressure Variability
Home Blood Pressure Monitoring in Prehypertension and Hypertension
Morning Surge of Blood Pressure in Prehypertension and Hypertension
Physical Activity and Exercise Training as Important Modifiers of Vascular Health
Role of Ambulatory Blood Pressure Monitoring in Prehypertension
Sympathoadrenal Reactivity to Stress as a Predictor of Cardiovascular Risk Factors
End Organ Damage in Prehypertension
Early Cardiovascular Dysfunction in Prehypertension
Clinical Studies in Prehypertension
Neurogenic Mechanisms in Prehypertension and Pharmacologic Approaches to the Prevention and Treatment of Hypertension: Highlights of Professor Stevo Julius’ Scientific Contributions
The PREVER Study
Management of Prehypertension
Antihypertensive Drugs and Vascular Health
Management of Prehypertension and Hypertension in Women of Childbearing Age
Non-pharmacologic Approaches for the Management of Prehypertension
Prehypertension: A Case in Favor of Early Use of Diuretics
Prehypertension in the Era of Personalized Medicine in 2017
Treatment of High-Normal Blood Pressure in the Guidelines