Rouault T.A. (Ed.) Iron-Sulfur Clusters in Chemistry and Biology. Volume 2: Biochemistry, Biosynthesis and Human Diseases

2nd Edition. — Berlin/Boston, Germany: Walter de Gruyter GmbH, 2017. — 493 p. — ISBN: 3110479397.This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.A retrospective on the discovery of [Fe-S] cluster biosynthetic machineries in Azotobacter vinelandii
The ISC system and the different facets of Fe-S biology in bacteria
A stress-responsive Fe-S cluster biogenesis system in bacteria – the suf operon of Gammaproteobacteria
Sensing the cellular Fe-S cluster demand: a structural, functional, and phylogenetic overview of Escherichia coli IscR
Fe-S assembly in Gram-positive bacteria
Fe-S cluster assembly and regulation in yeast
The role of Fe-S clusters in regulation of yeast iron homeostasis
Biogenesis of Fe-S proteins in mammals
Delivery of iron-sulfur clusters to recipient proteins: the role of chaperone and cochaperone proteins
Iron-sulfur proteins and human diseases
Friedreich ataxia
Connecting the biosynthesis of the molybdenum cofactor, Fe-S clusters, and tRNA thiolation in humans
Iron-sulphur proteins and genome stability
Eukaryotic iron-sulfur protein biogenesis and its role in maintaining genomic integrity
DNA signaling by iron-sulfur cluster proteins
Iron-sulfur cluster assembly in plants
Origin and evolution of Fe-S proteins and enzymes