Nakanishi T. et al. (eds.) Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology

Springer, 2016. — 367 p. — ISBN: 978-4-431-54627-6This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and the Future
Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine
The Arterial Epicardium: A Developmental Approach to Cardiac Disease and Repair
Cell Sheet Tissue Engineering for Heart Failure
Future Treatment of Heart Failure Using Human iPSC-Derived Cardiomyocytes
Congenital Heart Disease: In Search of Remedial Etiologies
Left-Right Axis and Heterotaxy Syndrome
Left-Right Asymmetry and Human Heterotaxy Syndrome
Roles of Motile and Immotile Cilia in Left-Right Symmetry Breaking
Role of Cilia and Left-Right Patterning in Congenital Heart Disease
Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome
Cardiomyocyte and Myocardial Development
Single-Cell Expression Analyses of Embryonic Cardiac Progenitor Cells
Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest
Intercellular Signaling in Cardiac Development and Disease: The NOTCH pathway
The Epicardium in Ventricular Septation During Evolution and Development
S1P-S1p2 Signaling in Cardiac Precursor Cells Migration
Myogenic Progenitor Cell Differentiation Is Dependent on Modulation of Mitochondrial Biogenesis through Autophagy
The Role of the Thyroid in the Developing Heart
Valve Development and Diseases
Atrioventricular Valve Abnormalities: From Molecular Mechanisms Underlying Morphogenesis to Clinical Perspective
Molecular Mechanisms of Heart Valve Development and Disease
A Novel Role for Endocardium in Perinatal Valve Development: Lessons Learned from Tissue-Specific Gene Deletion of the Tie1 Receptor Tyrosine Kinase
The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse
TMEM100: A Novel Intracellular Transmembrane Protein Essential for Vascular Development and Cardiac Morphogenesis
The Role of Cell Autonomous Signaling by BMP in Endocardial Cushion Cells in AV Valvuloseptal Morphogenesis
The Second Heart Field and Outflow Tract
Properties of Cardiac Progenitor Cells in the Second Heart Field
Nodal Signaling and Congenital Heart Defects
Utilizing Zebrafish to Understand Second Heart Field Development
A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”
The Loss of Foxc2 Expression in the Outflow Tract Links the Interrupted Arch in the Conditional Foxc2 Knockout Mouse
Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice
Vascular Development and Diseases
Extracellular Matrix Remodeling in Vascular Development and Disease
The “Cardiac Neural Crest” Concept Revisited
Roles of Endothelial Hrt Genes for Vascular Development
Inositol Trisphosphate Receptors in the Vascular Development
Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice
Ductus Arteriosus
Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing?
The Multiple Roles of Prostaglandin E2 in the Regulation of the Ductus Arteriosus
Developmental Differences in the Maturation of Sarcoplasmic Reticulum and Contractile Proteins in Large Blood Vessels Influence Their Contractility
Fetal and Neonatal Ductus Arteriosus Is Regulated with ATP-Sensitive Potassium Channel
Conduction System and Arrhythmia
Regulation of Vertebrate Conduction System Development
Cardiac Pacemaker Development from a Tertiary Heart Field
Endothelin Receptor Type A-Expressing Cell Population in the Inflow Tract Contributes to Chamber Formation
Specific Isolation of HCN4-Positive Cardiac Pacemaking Cells Derived from Embryonic Stem Cells
Current Molecular Mechanism in Cardiovascular Development
Combinatorial Functions of Transcription Factors and Epigenetic Factors in Heart Development and Disease
Pcgf5 Contributes to PRC1 (Polycomb Repressive Complex 1) in Developing Cardiac Cells
Noncoding RNAs in Cardiovascular Disease
iPS Cells and Regeneration in Congenital Heart Diseases
Human Pluripotent Stem Cells to Model Congenital Heart Disease
Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes