Wigley Fredrick M., Herrick Ariane L., Flavahan Nicholas A. (eds.) Raynaud’s Phenomenon: A Guide to Pathogenesis and Treatment

Springer, 2015. — 400 p. — ISBN: 978-1-4939-1525-5Raynaud’s Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud’s Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP. The work offers differential diagnosis options, reviews potential causes such as autoimmune disease, industrial trauma, drugs, and metabolic causes and provides clear recommendations for therapy. Engaging readers with case vignettes and a plethora of visual aids, Raynaud’s Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes.Historical Perspective of Raynaud’s Phenomenon
Definition, Nomenclature, and Diagnostic Criteria
Epidemiology of Raynaud’s Phenomenon
Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular System
Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud’s Phenomenon
Primary Raynaud’s Phenomenon
Raynaud Phenomenon in the Pediatric Age
Secondary Raynaud’s Phenomenon
Traumatic Vasospastic Disease
Other Secondary Causes
Raynaud’s Mimics
Nailfold Capillaroscopy
Non-invasive Methods of Assessing Raynaud’s Phenomenon
Angiography
Autoantibodies in Raynaud’s Phenomenon
Systemic Vasospasm
Clinical Outcome Measures in Raynaud’s Phenomenon
Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon
Non-drug Approaches to Treating Raynaud’s Phenomenon
Drug Treatment of Raynaud’s Phenomenon
Management of Digital Ischemia
Surgical Management
Practical Approaches to Treatment: Case Studies