Pfister D., Nicoud L., Morbidelli M. Continuous Biopharmaceutical Processes: Chromatography, Bioconjugation, and Protein Stability

Cambridge University Press, 2018. — 349 p. — ISBN: 978-1-108-42022-8.This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modeling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.Introduction to biopharmaceutical processes
Fundamentals of protein chromatography
Counter-current separation processes
Counter-current chromatography for the capture step
Counter-current chromatography for the polishing steps
Protein conjugation
Protein aggregation in biopharmaceutical processesTrue PDF