Kratz Felix, Senter Peter, Steinhagen Henning (eds.) Drug Delivery in Oncology: From Basic Research to Cancer Therapy - 3 Volume Set

Wiley-VCH, 2012. — 1738 p.In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.Principles of Tumor Targeting.
Limits of Conventional Cancer Chemotherapy.
Pathophysiological and Vascular Characteristics of Tumors in Relation to Drug Delivery.
Enhanced Permeability and Retention Effect in Relation to Tumor Targeting.
Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design.
Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates.
Antibody-Directed Enzyme Prodrug Therapy (ADEPT).
Basic Principles and its Practice So Far.
Tumor Imaging.
Imaging Techniques in Drug Development and Clinical Practice.
Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery.
Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT.Macromolecular Drug Delivery Systems.
Polymer-Based Systems.
Nano- and Microparticulate Drug Delivery Systems.
Lipid-Based SystemsLigand-Based Drug Delivery Systems
Special Topics.