Manca D. (ed.) Quantitative systems pharmacology: models and model-based systems with applications

Boston: Elsevier, 2018. — 417 p.Introduction to Quantitative Systems Pharmacology
Fundamentals of quantitative pharmacology
Multiscale modeling, from cells to membranes, tissues, organs, and systems/body
Pharma vectors and drug delivery systems
Drug release mechanisms
Anatomy of mammals and specifically of humans
Physiology of mammals and specifically of humans
Role of gender, race, age, body mass/surface, genetics, diseases on organs/tissues efficiency
Scalability among mammals: mice, rats, cats, dogs, horses, monkeys, humans
Administration, distribution, metabolism, and excretion mechanisms
In silico, in vitro, and in vivo models/data
Pharmacokinetic models (compartmental and physiologically based) for different drugs and administration pathways
Pharmacodynamic models
Multiscale models of PK and PD (from cells to whole body)
Allometric formula for interspecies adaptation of PK/PD models
Personalization of treatments
Monitoring and control of drug administration with applied case studies
Design of experiments, model identification and identifiability of models
Applications to drug individualized treatments and surgical operations
Methods and models for diagnosis of diseases
Challenges to develop model-based systems