Borea P.A., Varani K., Gessi S., Merighi S., Vincenzi F. (eds.) The Adenosine Receptors

Humana Press, 2018. — 603 p. — (The Receptors).This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.Adenosine Receptors: The Status of the Art
Regulation of Extracellular Adenosine
Adenosine Receptors: Structure, Distribution, and Signal Transduction
A1 Adenosine Receptor Agonists, Antagonists, and Allosteric Modulators
A2A Adenosine Receptor: Structures, Modeling, and Medicinal Chemistry
Medicinal Chemistry of A2B Adenosine Receptors
Medicinal Chemistry of the A3 Adenosine Receptor
Binding Thermodynamic Characteristics of Adenosine Receptor Ligands
Adenosine Receptors and Neuroinflammation
Adenosine Receptors as a Paradigm to Identify Dimer/Oligomers of G-Protein-Coupled Receptors and as Targets in Parkinson’s Disease and Schizophrenia
Adenosine Receptors in Alzheimer’s Disease
What Is the Role of Adenosine Tone and Adenosine Receptors in Huntington’s Disease?
Role of Adenosine Receptors in Epileptic Seizures
Adenosine and Oxygen/Glucose Deprivation in the Brain
The Adenosine Receptor: A Homeostatic Neuromodulator for Fine-Tuning Control of Cognition
The Adenosine-Receptor Axis in Chronic Pain
Adenosine Signalling in the Injured Heart
Adenosine Receptors in the Lungs
Renal Adenosine in Health and Disease
Adenosine Regulation of the Immune System
Adenosine Receptors Regulate Bone Remodeling and Cartilage Physiology
Adenosine Receptors in Gestational Diabetes Mellitus and Maternal Obesity in Pregnancy
Adenosine Receptors and Current Opportunities to Treat Cancer
Role of Adenosine Receptors in Clinical Biophysics Based on Pulsed Electromagnetic Fields