Singh R., Lillard Jr. J.W. Nanoparticle-based targeted drug delivery

Article. – Experimental and Molecular Pathology. - 2009. - Vol. 86.—P. 215–223.Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the nanometer size range. These nano-sized objects, e.g., nanoparticles, take on novel properties and functions that differ markedly from those seen from items made of identical materials. The small size, customized surface, improved solubility, and multi-functionality of nanoparticles will continue to open many doors and create new biomedical applications. Indeed, the novel properties of nanoparticles offer the ability to interact with complex cellular functions in new ways. This rapidly growing field requires cross-disciplinary research and provides opportunities to design and develop multifunctional devices that can target, diagnose, and treat devastating diseases such as cancer. This article presents an overview of nanotechnology for the biologist and discusses the attributes of our novel XPclad nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.Nanoparticle delivery systems
Applications and advantages of nanoparticle drug carriers
Characteristics important for drug delivery using nanoparticles
Particle size
Surface properties of nanoparticles
Drug loading
Drug release
Targeted drug delivery
Nanotechnology-based drug delivery in cancer
Hydrogels
Micelles and liposomes
Nanomaterial formulation
Nanosystems
Nanocells
Dendrimers
Nanotubes
Polymersomes
Quantum dots
XPclad nanoparticles