Baethmann A., Go K.G., Unterberg A. (eds.) Mechanisms of Secondary Brain Damage

New York: Springer, 1986. — 402 p.A distinction between primary and secondary brain damage of vari­ ous origin, particularly in acute lesions, such as head injury and ische­ mia is not entirely new. The concept is of practical significance, be­ cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam­ age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro­ vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho­ logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon­ cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.Primary Brain Damage in NonMissile Head Injury
Diffuse Axonal Injury — A New Conceptual Approach to an Old Problem
Histopathology and Computerized Tomography of Human Traumatic Cerebral Swelling
The Temporal Genesis of Primary and Secondary Brain Damage in Experimental and Clinical Head Injury
Evolution of Neuronal Ischemic Injury
Secondary Changes in Human and Experimental Brain Infarction with Particular Consideration of Microembolism
Ischemic Brain Damage in the Rat in a Long Term Recovery Model
Microthrombosis: A Contributing Factor to the Progression of Cerebral Infarction in Man
The CT Normal But Low Flow Infarct Periphery: Selective Neuronal Necrosis?
Disturbances of Extracellular Homeostasis after a Primary Insult as a Mechanism in Secondary Brain Damage
Role of Mediator Compounds in Secondary Brain Damage — Current Evidence
Neurochemical Sequelae of Brain Damage and Their Role in Functional Disturbances
Changes in Brain Edema Movement Following Experimental Brain Insults and Acute Therapy
Disturbances of Cellular Membranes and MembraneBound Enzymes in Cryogenic Brain Edema
Modifications of cAMP and Creatine KinaseIsoenzymes in CSF in Experimental Head Injury
Cell Swelling Mechanisms in Brain
Progression and Irreversibility in Brain Ischaemia
The Role of Recirculation for Functional and Metabolic Recovery After Cerebral Ischemia
PostIschemic Pathophysiology in the Gerbil Brain — Changes of Extracellular K + and Ca ++
Role of Synaptic Transmission Failure in the Neurologic Deficit of Ischemic Brain Injury
Increased Vulnerability of the Traumatized Brain to Early Ischemia
Recent Advances in the Study of Cerebrovascular Receptors
Role of Cerebral Microcirculation in Secondary Brain Damage
Influence of Experimental Hydrocephalus on Cerebral Vascularization
Avoidable Mortality Morbidity and Secondary Brain Damage After Recent Head Injury
Relevance of Primary and Secondary Brain Damage for Outcome of Head Injury
Can Secondary Brain Damage be Prevented by Pharmacological or other Means?
Contusional Hemorrhage — Prognostic Significance of Primary and Secondary Brain Damage
Systematic Search for Brain Resuscitation Potentials after Total Circulatory Arrest
Non Steroidal and Non Barbiturate Treatment of Secondary Brain Damage
Feasibility of Preventive Brain Protection in Patients at Excessive Risk of Stroke