Kropotov J.D. Functional Neuromarkers for Psychiatry. Applications for Diagnosis and Treatment

New York: Academic Press, 2016. — 452 p.Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail-what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders.
The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.
Identifies specific brain activation patterns that are neuromarkers for psychiatric disordersIncludes neuromarkers as seen via fMRI, PET, qEEG, and ERPsAddresses neuromarkers for ADHD, schizophrenia, and OCD in detailProvides information on using neuromarkers for diagnosis and/or personalized treatmentEntitled to full textMethods of assessing neuromarkersTheory of Measurement
Psychometrics and Neuropsychological Assessment
Functional Magnetic Resonance Imaging
Positron Emission Tomography
Spontaneous Electroencephalogram
Event-Related PotentialsInfraslow Electrical Oscillations
Alpha Rhythms
Beta and Gamma Rhythms
Frontal Midline Theta Rhythm
Sensory Systems and Attention Modulation
Executive System and Cognitive Control
Affective System, Emotions, and Stress
Memory Systems
Pharmacological Approach
Neurofeedback
Electroconvulsive Therapy
Transcranial Direct Current Stimulation
Transcranial Magnetic Stimulation
Deep Brain Stimulation
Attention Deficit Hyperactivity Disorder
Schizophrenia
Obsessive–Compulsive DisorderWorking Hypothesis
Technical Implementation
Testing Working Hypotheses: Spontaneous EEG
Testing Working Hypotheses: Event-Related Potentials
Monitoring Treatment Effects
Objective Measures of Human Brain Functioning
Rhythms of the Healthy Brain
Information Flow in the Healthy Brain
Current Treatment Options in Psychiatry
Functional Neuromarkers in Diseased Brain
Implementation in Clinical Practice
PostscriptumFurther Readings