Aschner M., Costa L. Neurotoxicity of metals

New York: Springer, 2017. — 377 p.Developmental Neurotoxicity
Developmental Neurotoxicity of LeadDevelopmental Exposures to Lead
Neurobehavioral Effects of Lead
Molecular Mechanisms of Neurotoxicity
Developmental Exposures to Lead and Alzheimer's DiseaseManganese and Developmental Neurotoxicity
Manganese in the Environment
Airborne Particles
Deposited Dust
Surface Soil
Edible Vegetables
Drinking Water
Toxicology and Biomarkers
Metabolism
Pediatric Absorption
Biomarkers
Effects on Cognitive Functions
Intellectual Ability Executive Function Memory
Academic Achievement
Effects on Motor Functions
Behavior
Attention Deficit Hyperactivity Disorder
Autism Spectrum Disorder
Other Behavioral Outcomes
Effects on Olfactory FunctionInherited Disorders of Manganese MetabolismSLC30A10
SLC39A14
SLC39A8
Concluding PerspectivesNeurodegenerative DisordersChemical Speciation of Selenium and Mercury as Determinant of Their NeurotoxicitySelenium in the Environment and in the Living Organisms
Selenium: Neurotoxic or Neuroprotector? From Selenide to Selenoproteins Selenoproteins in the Brain
Mercury in the Environment and in the Living Organisms
Inorganic Mercury Neurotoxicity
Organic Mercury Neurotoxicity
Selenium and Mercury: Brain Antagonistic Interactions
Selenium as Antagonist of Inorganic Mercury Neurotoxicity
Selenium as an Antagonist of the Neurotoxicity Induced by Organic MercuryMetals and ParaoxonasesPON1
Human Polymorphisms of PON1 and Definition of PON1 Status
Modulation of PON1 Activity and Expression
PON2 PON2 as an Intracellular Antioxidant Enzyme Modulation of PON2
PON3: Activity, Polymorphisms, Physiological Functions, and Modulation
Interactions of Metals with PONs
In Vitro Effects of Metals on PONs
Effects of Metals on PONs: Animal Studies
Metals and PONs: Human Studies
Lead
Arsenic
Methylmercury and Selenium
Cadmium
Other Metals
Potential Mechanisms of PON1 Modulation by Metals
Summary and ConclusionsManganese and the Insulin-IGF Signaling Network in Huntington's Disease and Other Neurodegenerative Disorders
Introduction IIS Signaling and Its Role in the Brain Mn and Insulin/IGF Homeostasis
HD Pathobiology
Mn Dysregulation in HD
IIS Dysregulation in HD
Autophagy Deficits in HD, Potential Links to Mn and IIS
Mitochondrial Pathology in HD, Possible Links to Mn and IIS
IIS Signaling and Mn in Other NDDs
PD and IIS/Mn
AD and IIS/Mn
ALS and IIS/Mn
Autophagy in Other Neurodegenerative Diseases
Manganese Toxicity and IGF
The Co-regulation of ATM, Mn, and Insulin/IGF
IIS Signaling, Mn, and CancerOccupational Metal Exposure and Parkinsonism