Gubernator Klaus, Bohm Hans-Joachim (eds.) Structure-Based Ligand Design. Methods and Principles in Medicinal Chemistry

Wiley-VCH, 1998. — 159 p.Writing or editing a book about a rapidly evolving area of science is a challenge. Doing this while being involved in real projects every day is even more of a challenge. And changing location and assignment during this exercise (which is true for both editors) adds further hurdles.
We are thus particularly glad to now present a series of real-life stories from practitioners in the field that have been selected to reflect the current status of structure-based design, it’s achievements and also it’s controversies. These are embedded in review-type methodological chapters and discussions about scope and future perspectives of these approaches. Our personal summary from writing several chapters and editing others is that structure-based design actually works and it’s successes are now well documented. It cannot be applied to every project and the explosion of biostructural information has just started, dramatically broadening the scope of structure-based design in the future. The methodologies exploiting
this information are still evolving and there is room for completely new approaches. This makes this field so interesting, in addition to the beauty of the 3D-structure, and makes writ ing an account or review so rewarding. We would like to thank the contributors for the nice collaboration that we had. We also would like to acknowledge the continuous high interest of the series editors in this book project and their very valuable comments and suggestions on earlier versions of this work. We would also like to extend our thanks to our employers who fully support these additional
activities, and to our families who have suffered from our mental absence for more than one weekend.