Wang Y., Lin D., Gout P.W. (Eds.) Patient-Derived Xenograft Models of Human Cancer

Springer International Publishing AG, 2017. — 212 p. — (Molecular and Translational Medicine) — ISBN: 3319558242.This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text.Patient-Derived Tumor Xenografts: Historical Background
Towards Best Practice in Establishing Patient-Derived Xenografts
Fidelity and Stability of PDX Models
Humanized Mouse and Rat PDX Cancer Models
Studies of Cancer Heterogeneity Using PDX Models
The Plasticity of Stem-Like States in Patient-Derived Tumor Xenografts
Modeling Cancer Metastasis
Modeling Drug Resistance in PDX Models
Using PDX for Biomarker Development
Patient-Derived Xenografts as Cancer Models for Preclinical Drug Screening
First-Generation Tumor Xenografts: A Link Between Patient-Derived Xenograft Models and Clinical Disease
Application of PDX Cancer Models in Co-clinical Trials and Personalized/Precision Medicine
Prospectives