Dabrowiak James C. Metals in Medicine

John Wiley & Sons, Ltd, 2009. — 321 p. — ISBN 978-0-470-68196-1; ISBN 978-0-470-68197-8.Feature BoxesInorganic Chemistry Basics
Crystal field theory
Octahedral crystal field
Other crystal fields
Factors affecting the crystal field splitting parameter, D
High- and low-spin complexes
Molecular orbital theory
MO diagram of molecular hydrogen
MO diagram for [Co(NH₃)₆]₃þ
Absorption spectra of metal complexes
Band intensity/selection rules
Spectroscopic and crystal field terms
Band assignments and D
Magnetic properties of metal complexes
Reactions of metal complexes
Forward and reverse rates and equilibrium
Water exchange rates for metal ions
Transition State Theory, the kinetic rate constant and equilibrium
Trans effect and substitution reactions
Stability of metal complexes
Chelate effect
Macrocyclic effect
Hardsoft acidsbasesFurther reading
Metallo-Drugs and Their ActionProteins as targets for metallo-drugs
Protein structure
Metal binding sites on proteins
DNA as a target for metallo-drugs
Structure of DNA and RNA
Metal binding sites on DNA
Reaction of metal complexes in the biological milieu
Reactions with chloride
Reactions with phosphate
Reactions with carbonate
Evaluating the pharmacological effects of agents
Measuring the cytotoxicity of a drug
Measuring drug uptake
Animal studies
From discovery to the marketplace
Drug approval process
ProfitsFurther reading
Cisplatin
Physical and chemical properties of cisplatin
Formulation, administration and pharmacokinetics
Reaction of cisplatin in biological media
Uptake, cytotoxicity and resistance
Influx and efflux of cisplatin
Modification by glutathione and metallothionein
DNA repair
Other resistance mechanisms
Interaction of cisplatin with cellular targets
DNA as a target
Non-DNA targetsFurther reading
Platinum Anticancer Drugs
Carboplatin
Synthesis and properties of carboplatin
Formulation, administration and pharmacokinetics of carboplatin
Reactions of carboplatin in the biological milieu
Cytotoxicity and uptake of carboplatin
Interaction of carboplatin with cellular targets
[b]Oxaliplatin[/b]
Stereochemistry of oxaliplatin
Synthesis and properties of oxaliplatin
Formulation, administration and pharmacokinetics of oxaliplatin
Reaction of oxaliplatin in the biological milieu
Cytotoxicity and uptake of oxaliplatin
Interaction of oxaliplatin with cellular targets
New platinum agents
Nedaplatin
Lobaplatin
Heptaplatin
Satraplatin (JM216)
Picoplatin (AMD473, ZD473)
BBRFurther reading
Ruthenium, Titanium and Gallium for Treating Cancer
Ruthenium compounds for treating cancer
Chemistry of ruthenium in the biological milieu
Structure, synthesis and properties of ruthenium antitumor agents
Synthesis and biological properties of NAMI-A
Control of tumor growth by NAMI-A
Clinical trials with NAMI-A
Interaction of NAMI-A with potential biological targets
Synthesis and biological properties of KP
Biological activity of KP
Clinical trials with KP
Interaction of KP1019 with potential biological targets
Synthesis and properties of ruthenium arene compounds
Biological activity of the arene complexes
Targets of the ruthenium arene compounds
Titanium compounds for treating cancer
Structure, synthesis and properties of titanocene dichloride
Interaction of titanocene dichloride with potential biological targets
Structure, synthesis and properties of budotitane
Antitumor activity and clinical trials with budotitane
Biological interactions of budotitane
Titanium anticancer drugs in development
Gallium for treating cancer
Chemistry of gallium in biological media
Structures, synthesis and properties of gallium anticancer agents
Uptake, cytotoxicity and reactivity of gallium agents in the biological system
Gallium anticancer agents in developmentFurther reading
Gold Compounds for Treating Arthritis, Cancer and Other Diseases
Chemistry of gold in biological media
Gold compounds for treating arthritis
Structures, synthesis and properties of gold antiarthritic drugs
Formulation, administration and pharmacokinetics of gold antiarthritic drugs
Reactions in biological media, uptake and cytotoxicity of gold drugs
Interactions with cellular targets
Gold complexes for treating cancer
Structures, synthesis and properties of gold anticancer agents
Reactions in biological media, uptake and cytotoxicity of gold anticancer agents
Reactions with cellular targets
Gold complexes for treating AIDS and other diseasesFurther reading
Vanadium, Copper and Zinc in Medicine
Vanadium for treating diabetes
Diabetes mellitus (DM)
Bis(ethylmaltolato)oxovanadium(IV), BEOV and
bis(maltolate)oxovanadium(IV), BMOV
Bis(acetylacetonato)oxovanadium(IV), VO(acac)2, bis(picolinato)oxovanadium(IV), VO(pic)2 and oxodiperoxo(1,10-phenanthroline)vanadium(V), [bpV(phen)]
Anticancer effects of vanadium compounds
Role of copper and other metal ions in Alzheimers disease
Metal chelating agents for treating Alzheimers disease
Complexes of the amyloid beta (Ab) peptide
Radical production in AD
Copper in Wilsons and Menkes diseases
Zincbicyclam: a chemokine receptor antagonistFurther reading
Metal Complexes for Diagnosing Disease
Technetium in diagnostic nuclear medicine
Clinically used ⁹⁹mTc imaging agents
Technetium imaging agents for selective targeting
Innovations in synthesis, the [Tc(CO)₃] þ core
Metal compounds as contrast agents for MRI
Clinically used MRI contrast agents
Contrast agents in development
Iron oxide particles
Radionuclides for palliative care and cancer treatmentFurther reading
Nanomedicine
Nanoscience for treating disease
Single walled carbon nanotubes
Metalorganic frameworks
Mesoporous silica
Encapsulation
Gold nanoparticles
Nanomedicine in diagnosing disease
Computed tomography
Magnetic resonance imaging
Quantum dots
Potential health risks of nanoparticles
Cell culture assays and nanomaterials
Cytotoxicity of nanoparticlesFurther reading