Spangler S. Accelerating Discovery. Mining Unstructured Information for Hypothesis Generation

Springer, 2016. — 304 p.As the volume of scientific data and literature increases exponentially, scientists need more powerful tools and methods to process and synthesize information and to formulate new hypotheses that are most likely to be both true and important. Accelerating Discovery: Mining Unstructured Information for Hypothesis Generation describes a novel approach to scientific research that uses unstructured data analysis as a generative tool for new hypotheses.
The author develops a systematic process for leveraging heterogeneous structured and unstructured data sources, data mining, and computational architectures to make the discovery process faster and more effective. This process accelerates human creativity by allowing scientists and inventors to more readily analyze and comprehend the space of possibilities, compare alternatives, and discover entirely new approaches.
Encompassing systematic and practical perspectives, the book provides the necessary motivation and strategies as well as a heterogeneous set of comprehensive, illustrative examples. It reveals the importance of heterogeneous data analytics in aiding scientific discoveries and furthers data science as a discipline.Why Accelerate Discovery?
Form and Function
Exploring Content to Find Entities
Organization
Relationships
Inference
Taxonomies
Orthogonal Comparison
Visualizing the Data Plane
Networks
Examples and Problems
Problem: Discovery of Novel Properties of Known Entities
Problem: Finding New Treatments for Orphan Diseases from Existing Drugs
Example: Target Selection Based on Protein Network Analysis
Example: Gene Expression Analysis for Alternative Indications
Example: Side Effects
Example: Protein Viscosity Analysis Using Medline Abstracts
Example: Finding Microbes to Clean Up Oil Spills
Example: Drug Repurposing
Example: Adverse Events
Example: P53 Kinases
Conclusion and Future Work