Bryan N.S., Loscalzo J. (Eds.) Nitrite and Nitrate in Human Health and Disease

Springer Science+Business Media, LLC, 2011. — 330 p. — (Nutrition and Health) — ISBN: 3319461877Our major objective and driving force in developing Nitrite and Nitrate in Human Health and Disease is to consolidate all the key research and knowledge in one volume in order to establish a framework based on the totality of evidence for nitrite and nitrate and the effects of these two anions on human health and disease. Although the biomedical science community is excited and optimistic about the potential for developing new therapeutics and perhaps regimens of disease prevention based on their ability to generate nitric oxide under appropriate conditions, epidemiologists, nutritionists, and cancer biologists have cause for concern due to the inherent nitrosative chemistry of nitrite and NO that could form potentially carcinogenic N-nitrosamines. This is the first book in the Springer/Humana Nutrition Series dedicated to understanding the nutritional aspects of nitrite and nitrate for human health. It is our intent to deliver a comprehensive review of nitrite and nitrate, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body.Basic Biochemistry, Metabolism, and PhysiologyFrom Atmospheric Nitrogen to Bioactive Nitrogen Oxides
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Sources of Exposure to Nitrogen Oxides
Food and Environmental Exposures to Nitrite and Nitrate
History of Nitrite and Nitrate in Food
Nutritional Epidemiology of Nitrogen Oxides: What do the Numbers Mean?
Nutritional Impact on the Nitric Oxide Pathway
Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases
Nitrite and Nitrate in Human Breast Milk: Implications for Development
Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks
Nitrite and Nitrate in Therapeutics and Disease
Nitric Oxide Signaling in Health and Disease
Inhaled Nitric Oxide
Pharmacology of Nitrovasodilators
Nitrite and Nitrate in Ischemia-Reperfusion Injury
The Nitrate–Nitrite–Nitric Oxide Pathway in Traditional Herbal Medicine for Heart Disease
Nitrite and Nitrate in Cancer
Looking Forward