Gerecht Sh. (Ed.) Biophysical Regulation of Vascular Differentiation and Assembly

Springer Science+Business Media, 2011. - 253 p.Because of their ability to differentiate and develop into functional vasculature, stem cells hold tremendous promise for therapeutic applications. However, the scientific understanding and the ability to engineer these cellular systems is still in its early stages, and must advance significantly for the therapeutic potential of stem cells to be realized. Stem cell differentiation and function are exquisitely tuned by their microenvironment. This book will provide a unique perspective of how different aspect of the vasculature microenvironment regulates differentiation and assembly. Recent efforts to exploits modern engineering techniques to study and manipulate various biophysical cues will be described including: oxygen tension during adult and embryonic vasculogenesis, extracellular matrix during tube morphogenesis and angiogenesis, surface topography and modification, shear stress and cyclic strain effect on vascular assembly and maturation, and three dimensional space for angio-andvasculogensis.Embryonic and Adult Stem Cells in Vasculogenesis and Angiogenesis
Extracellular Matrix and Matrix Metalloproteinase in Vascular Morphogenesis
Scaffolding for Three-Dimensional Embryonic Vasculogenesis
Matrix Viscoelasticity and Remodeling During 3D Vascular Assembly
Biomechanical Properties of Implanted Scaffolds Affect Human Blood Vessel Formation From Circulating Endothelial Colony Forming Cells
Oxygen Regulation of Adult Angiogenesis
Hypoxia During Embryonic Vascular Development and Differentiation
Three-Dimensional Regulation During Cancerous Angiogenesis
Microfluidics to Control Shear and Oxygen Flow for Vascular Differentiation
Cyclic Strain and Surface Shape for Engineered Vasculature Constructs
Matrix Topography and Viscoelasticity Guide Vascular Assembly.