Kumar R. (Ed.) Nuclear Signaling Pathways and Targeting Transcription in Cancer

New York: Humana Press, 2014. — 439 p. — (Cancer Drug Discovery and Development). — ISBN: 978-1-4614-8038-9, 978-1-4614-8039-6.At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the “classic” papers as well as perspectives on future directions for the field.Gene Regulation and Cancer
Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression
Role of Alteration/Defi ciency in Activation (ADA) Complex in Cell Cycle, Genomic Instability and Cancer
RUNX2 Transcriptional Regulation in Development and Disease
Epigenetic Mechanisms of Cancer MetastasisSignaling Pathway and Cancer
Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications
Nuclear Factors Linking Cancer and Inflammation
Regulation of the Jak/STATs Pathways by Histone Deacetylases
Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers
Nucleolar Signaling Determines Cell Fate: The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis
Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer TreatmentProtein Domains and Cancer Therapeutics
Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology
Domain Specifi c Targeting of CancerTargeted Cancer Therapy
The Potential of Targeting Splicing for Cancer Therapy
Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies
Histone Demethylases in Prostate Cancer
Therapeutic Signifi cance of Chromatin Remodeling Complexes in Cancer